{"id":"W3083249075","doi":"10.1158/1538-7445.am2020-lb-079","title":"Abstract LB-079: Microbubble mediated focused ultrasound therapy enhances the antitumor potency and durability of anti-PD-L1 checkpoint blockade","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital","funders":"","keywords":"Medicine; Blockade; Paclitaxel; Immune checkpoint; Immunotherapy; Cancer research; Toxicity; Breast cancer; Triple-negative breast cancer; Cancer; Pharmacology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257341,0.0002940068,0.0002842035,0.0002731518,0.0000926898,0.000219624,0.0002070957,0.0003842681,0.002630986],"category_scores_gemma":[0.00005997411,0.00009222322,0.0001872658,0.0001164636,0.0002117533,0.0002208747,0.0001523192,0.0007568183,0.0004289884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002532829,"about_ca_system_score_gemma":0.0002118157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007336334,"about_ca_topic_score_gemma":0.0008891217,"domain_scores_codex":[0.999909,0.00001572195,0.000005158778,0.0000164823,0.00002375042,0.00002994119],"domain_scores_gemma":[0.999954,0.000007515333,0.00001277008,0.00000314546,0.000004619926,0.00001798584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006565899,0.0002778625,0.00008400941,0.00005558479,0.000006111858,0.00002856385,0.00001052668,0.0001461679,0.9932271,0.0001068648,0.0003439439,0.005056803],"study_design_scores_gemma":[0.00009865779,0.003895747,0.001609401,0.000008649469,0.0000246788,0.0001245764,0.00001444145,0.001619439,0.9896833,0.00002843402,0.002887989,0.00000471067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892592,0.003190979,0.003057126,0.0003282172,0.0000842594,0.00005143115,0.0003291096,0.0002724306,0.00342724],"genre_scores_gemma":[0.9916933,0.0009609487,0.001951831,0.0001214705,0.00002430179,0.00004034871,0.0003658529,0.00001730158,0.004824464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002630986,"threshold_uncertainty_score":0.00880152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05455394360473243,"score_gpt":0.3141290801629285,"score_spread":0.2595751365581961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}