{"id":"W3083291269","doi":"10.1158/1538-7445.am2020-2206","title":"Abstract 2206: Degradation of hyaluronan in the tumor microenvironment enhances oncolytic reovirus and anti-PD-L1 therapy in a murine syngeneic breast tumor model","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Tumor microenvironment; Oncolytic virus; Cancer research; Immunotherapy; Cytotoxic T cell; CD8; Medicine; Immune system; Combination therapy; Immune checkpoint; Cancer immunotherapy; Immunology; Chemistry; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002057203,0.0005996719,0.0003268194,0.0003405154,0.0001387296,0.0002619192,0.0002309894,0.0004452742,0.0009971205],"category_scores_gemma":[0.00006884948,0.0001678692,0.0003362108,0.0001603582,0.0002406408,0.0002783115,0.000146728,0.000923046,0.0003005401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003716963,"about_ca_system_score_gemma":0.0002457068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006492968,"about_ca_topic_score_gemma":0.0007130047,"domain_scores_codex":[0.9997926,0.00002858281,0.00001612222,0.00004601877,0.00005588157,0.00006081874],"domain_scores_gemma":[0.9998803,0.00001368471,0.00003634036,0.00001556226,0.00001091038,0.00004307938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002091314,0.000132796,0.00006586224,0.00001894578,0.000003615569,0.00002297912,0.000009765584,0.0000885812,0.9987541,0.0000688785,0.00003080487,0.0005944608],"study_design_scores_gemma":[0.00002778598,0.001045775,0.0007830787,0.000002748373,0.000009477552,0.0000985107,0.000009573763,0.0009682313,0.9963296,0.00001849915,0.0007042924,0.000002326602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956847,0.0007185537,0.00191646,0.0001015656,0.00003701352,0.00005863115,0.000415167,0.00007519148,0.0009926279],"genre_scores_gemma":[0.9933143,0.0004363045,0.002461042,0.00005006911,0.00001170874,0.00007139108,0.000529008,0.0000209179,0.003105226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009971205,"threshold_uncertainty_score":0.003335714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05524992588290677,"score_gpt":0.3604776246868621,"score_spread":0.3052276988039553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}