{"id":"W3083296688","doi":"10.1101/2020.09.04.20187575","title":"Genome-wide analysis identifies significant contribution of brain-expressed genes in chronic, but not acute, back pain","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Musculoskeletal pain and rehabilitation","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Norwegian Institute of Public Health; Statens Serum Institut; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Norges Forskningsråd; Helse Midt-Norge; Canada Excellence Research Chairs, Government of Canada; National Institutes of Health; Faculty of Medicine and Health, University of Sydney; Norges Teknisk-Naturvitenskapelige Universitet","keywords":"Chronic pain; Back pain; Acute pain; Medicine; Cohort; Genome-wide association study; Bioinformatics; Gene; Biology; Genetics; Internal medicine; Physical therapy; Single-nucleotide polymorphism; Anesthesia; Pathology; Genotype; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003412561,0.0002364478,0.0002803676,0.0004757985,0.0002118472,0.0004557223,0.0002054887,0.0003057847,0.00332862],"category_scores_gemma":[0.0008073366,0.0001433337,0.0004956968,0.0006140569,0.0002502633,0.0001071561,0.0003513679,0.0003914017,0.0002511604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001206698,"about_ca_system_score_gemma":0.0001867843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002406804,"about_ca_topic_score_gemma":0.002688833,"domain_scores_codex":[0.999686,0.00006047589,0.00001517978,0.0001405273,0.00004246108,0.00005540178],"domain_scores_gemma":[0.9994513,0.0002395611,0.0001627304,0.00005511682,0.00002955172,0.00006170637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002417552,0.0001213635,0.7281486,0.000442519,0.002755375,0.001708118,0.0003478745,0.0009424959,0.2361836,0.000568871,0.002330592,0.02403301],"study_design_scores_gemma":[0.00003782667,0.00007601615,0.9949404,0.00001773663,0.0003515369,0.0005259257,0.00007906812,0.0003139357,0.002533988,0.0003038614,0.0008126054,0.000007065885],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925321,0.001403542,0.001510179,0.0002094322,0.00002291166,0.00000643337,0.003660169,0.00003708043,0.0006182105],"genre_scores_gemma":[0.9963384,0.0004261286,0.0008293935,0.0001140748,0.00001752604,0.00001256534,0.001714106,0.00002122666,0.0005265045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00332862,"threshold_uncertainty_score":0.01113534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174260534438394,"score_gpt":0.281830371640897,"score_spread":0.2644043181970576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}