{"id":"W3083296688","doi":"10.1101/2020.09.04.20187575","title":"Genome-wide analysis identifies significant contribution of brain-expressed genes in chronic, but not acute, back pain","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Musculoskeletal pain and rehabilitation","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Norwegian Institute of Public Health; Statens Serum Institut; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Norges Forskningsråd; Helse Midt-Norge; Canada Excellence Research Chairs, Government of Canada; National Institutes of Health; Faculty of Medicine and Health, University of Sydney; Norges Teknisk-Naturvitenskapelige Universitet","keywords":"Chronic pain; Back pain; Acute pain; Medicine; Cohort; Genome-wide association study; Bioinformatics; Gene; Biology; Genetics; Internal medicine; Physical therapy; Single-nucleotide polymorphism; Anesthesia; Pathology; Genotype; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002324551,0.0003900688,0.001459924,0.0006392341,0.00003936358,0.00003302904,0.0002978699,0.0004238182,0.0003133787],"category_scores_gemma":[0.002032683,0.0003421101,0.0008353136,0.0008367806,0.0002288862,0.0000567244,0.0002543359,0.0005852357,0.00004330156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429841,"about_ca_system_score_gemma":0.0003671998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002694055,"about_ca_topic_score_gemma":0.0001771345,"domain_scores_codex":[0.9961488,0.0008494849,0.001182927,0.0008562659,0.0005983384,0.0003641954],"domain_scores_gemma":[0.997066,0.001031278,0.0005139342,0.000841862,0.000359388,0.0001875742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002321298,0.0001382045,0.1282513,0.003681672,0.001814253,0.00003173573,0.0004201499,0.001580526,0.8632571,0.0000279102,0.0001787263,0.0003863139],"study_design_scores_gemma":[0.001362539,0.0002869411,0.9281797,0.0004824161,0.001114062,3.371501e-7,0.000175137,0.008176587,0.05874106,0.0003347617,0.0007747564,0.0003716873],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770498,0.0009484715,0.01250339,0.007500346,0.0001866844,0.001499572,0.0001366381,0.00006230449,0.0001127837],"genre_scores_gemma":[0.996518,0.000483964,0.0004103786,0.0004143916,0.0002311789,0.0001292299,0.001406447,0.0000380193,0.0003683869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.804516,"threshold_uncertainty_score":0.9999031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174260534438394,"score_gpt":0.281830371640897,"score_spread":0.2644043181970576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}