{"id":"W3083297008","doi":"10.1101/2020.09.04.283838","title":"Chromatin State Dynamics Confers Specific Therapeutic Strategies in Enhancer Subtypes of Colorectal Cancer","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Enhancer; Epigenomics; Bromodomain; Chromatin; Colorectal cancer; Cancer research; Biology; Tumor progression; Enhancer RNAs; Cancer; Epigenetics; Computational biology; Genetics; Gene; Transcription factor; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468917,0.000203375,0.0002217737,0.0001792919,0.00007301995,0.000231823,0.0001280751,0.0001429973,0.0008566182],"category_scores_gemma":[0.0001017864,0.0001102768,0.0001698768,0.000100043,0.0001247659,0.0001197308,0.0001798599,0.0003687991,0.0001750672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001473942,"about_ca_system_score_gemma":0.0001113297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001789716,"about_ca_topic_score_gemma":0.0004177363,"domain_scores_codex":[0.9999132,0.000008686181,0.000005232004,0.00002512783,0.00002577718,0.00002200245],"domain_scores_gemma":[0.999949,0.000009055637,0.00001544031,0.00001070878,0.000005430173,0.00001029112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001500301,0.00003055668,0.0007062801,0.00002535486,0.000006567239,0.00002146811,0.000009439957,0.0002747244,0.9936795,0.0001650502,0.00003583706,0.004895226],"study_design_scores_gemma":[0.00001510141,0.0004577054,0.006044564,0.000002859948,0.00002464288,0.0002828878,0.00001621096,0.001535707,0.9894517,0.00009734911,0.002067035,0.000004195692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988597,0.001537211,0.007589817,0.00004843023,0.00001565862,0.00004911489,0.0003395995,0.0001471828,0.001676114],"genre_scores_gemma":[0.9961371,0.0003868868,0.002206702,0.00001980517,0.000004151208,0.00002370717,0.0002415732,0.00001440268,0.0009656409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008566182,"threshold_uncertainty_score":0.002865613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0117556853331086,"score_gpt":0.2344645610320551,"score_spread":0.2227088756989465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}