{"id":"W3083312313","doi":"10.1158/1538-7445.am2020-507","title":"Abstract 507: Repurposing of FDA approved drugs for treatment of metastatic HNSCC","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Repurposing; Medicine; Malignancy; Cancer; Metastasis; Disease; Drug repositioning; Drug discovery; Cancer research; Drug; Oncology; Bioinformatics; Internal medicine; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001579335,0.0004624127,0.0005461349,0.001117725,0.0002515883,0.0003745961,0.0002860113,0.0003468911,0.006067938],"category_scores_gemma":[0.0002055332,0.0001865083,0.0004712963,0.0006717264,0.0001627161,0.0001909648,0.0002390289,0.0004134554,0.001558704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003949045,"about_ca_system_score_gemma":0.0005424343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001477764,"about_ca_topic_score_gemma":0.003681331,"domain_scores_codex":[0.999856,0.00002131609,0.00001186687,0.00002283481,0.00005634459,0.0000315539],"domain_scores_gemma":[0.9999017,0.00002103529,0.00001613699,0.000009959761,0.00002983707,0.00002145436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003463497,0.0004114731,0.001203338,0.000378652,0.00005067056,0.000486376,0.00003792644,0.0008684719,0.9641057,0.0002530524,0.001944371,0.0299135],"study_design_scores_gemma":[0.0001701021,0.002821031,0.010455,0.00006297117,0.0001910954,0.001080288,0.00006285423,0.001835741,0.957376,0.0001130593,0.02579382,0.00003807858],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9472288,0.01201326,0.006677456,0.0006915294,0.0001714343,0.0009325632,0.01120749,0.0007755383,0.02030193],"genre_scores_gemma":[0.9338474,0.01069287,0.01518666,0.0009181863,0.0000664267,0.0003975409,0.02013847,0.0001402961,0.01861217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006067938,"threshold_uncertainty_score":0.02029926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1097385413920946,"score_gpt":0.4079024123085394,"score_spread":0.2981638709164448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}