{"id":"W3083335053","doi":"10.1371/journal.pone.0238224","title":"L-arginine effects on cerebrovascular reactivity, perfusion and neurovascular coupling in MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) syndrome","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Advanced MRI Techniques and Applications","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network; SickKids Foundation; Toronto Western Hospital; Hospital for Sick Children","funders":"United Mitochondrial Disease Foundation","keywords":"Mitochondrial encephalomyopathy; Cerebral blood flow; MELAS syndrome; Medicine; Lactic acidosis; Cardiology; Internal medicine; Visual cortex; Perfusion; Anesthesia; Endocrinology; Mitochondrial DNA; Biology; Neuroscience; Mitochondrial myopathy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009109428,0.0002231375,0.0005156253,0.00009850128,0.00008586049,0.00002259595,0.0000625428,0.00009627589,0.00000922564],"category_scores_gemma":[0.0001211181,0.0001925252,0.00004835846,0.0002544406,0.0000687104,0.0001367972,0.00008157046,0.0004330021,0.000005766735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000410523,"about_ca_system_score_gemma":0.00002478952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003053797,"about_ca_topic_score_gemma":0.00000578072,"domain_scores_codex":[0.9986143,0.00003074328,0.0001814925,0.0005554648,0.0003833337,0.0002347346],"domain_scores_gemma":[0.9991796,0.0001603828,0.00007459489,0.0003199881,0.00004584981,0.0002195704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006961315,0.001655697,0.03175679,0.0008368632,0.000147213,0.0003259368,0.000353317,0.0001243525,0.9599953,0.0002084994,0.00001096007,0.003888962],"study_design_scores_gemma":[0.01648919,0.01252464,0.09572716,0.004194671,0.002460741,0.0003796854,0.000234958,0.03634352,0.8293108,0.0001889507,0.000890012,0.001255617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931139,0.0003890744,0.00337394,0.001667691,0.00001116001,0.001240535,0.000005363444,0.0001420789,0.00005619919],"genre_scores_gemma":[0.9813045,0.0009382248,0.01699706,0.000403512,0.00008944801,0.0001866304,0.00001123947,0.00004665714,0.00002278653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1306844,"threshold_uncertainty_score":0.7850949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0206205390246841,"score_gpt":0.2290098490284851,"score_spread":0.208389310003801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}