{"id":"W3083341879","doi":"10.1158/1538-7445.am2020-6316","title":"Abstract 6316: High throughput small molecule screening with synthetic 3D lung-mimetic hydrogels in the rare lung cancer lymphangioleiomyomatosis","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Health Canada; Ottawa Hospital","funders":"","keywords":"Lymphangioleiomyomatosis; Cancer research; mTORC1; Viability assay; Cytotoxicity; Cell culture; Lung cancer; Cancer cell; Cell; Biology; Cancer; Cell biology; Pathology; Medicine; Biochemistry; Tuberous sclerosis; Internal medicine; Protein kinase B; Signal transduction; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00153519,0.0004011053,0.000660974,0.0004221449,0.0004066036,0.0002265135,0.001118812,0.0001785183,0.001751422],"category_scores_gemma":[0.0003753049,0.0002775301,0.0001533745,0.002758878,0.0005801243,0.0001726061,0.0003958685,0.001373771,0.00008343891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007817974,"about_ca_system_score_gemma":0.001130211,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009918288,"about_ca_topic_score_gemma":0.0008769455,"domain_scores_codex":[0.9936666,0.0006229446,0.0005023905,0.00108144,0.00241805,0.001708579],"domain_scores_gemma":[0.9969907,0.0008475309,0.00009375695,0.0009995804,0.0005183426,0.00055008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009324488,0.001891929,0.4652641,0.009903476,0.002896167,0.005955254,0.02873211,0.008646564,0.3430223,0.001168598,0.06702697,0.05616805],"study_design_scores_gemma":[0.02895968,0.003541367,0.6191772,0.02102926,0.001095791,0.0004592559,0.009502023,0.06502307,0.2343197,0.000147109,0.01318187,0.003563588],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563152,0.009852073,0.0004516272,0.02881335,0.00004664984,0.002499726,0.00007345363,0.0001179212,0.001830017],"genre_scores_gemma":[0.9939769,0.0006908753,0.0006534274,0.002011917,0.0004405673,0.001844009,0.00002618847,0.0001479328,0.0002081841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1539131,"threshold_uncertainty_score":0.9999677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1174391113757327,"score_gpt":0.3836898054415954,"score_spread":0.2662506940658627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}