{"id":"W3083341879","doi":"10.1158/1538-7445.am2020-6316","title":"Abstract 6316: High throughput small molecule screening with synthetic 3D lung-mimetic hydrogels in the rare lung cancer lymphangioleiomyomatosis","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Health Canada; Ottawa Hospital","funders":"","keywords":"Lymphangioleiomyomatosis; Cancer research; mTORC1; Viability assay; Cytotoxicity; Cell culture; Lung cancer; Cancer cell; Cell; Biology; Cancer; Cell biology; Pathology; Medicine; Biochemistry; Tuberous sclerosis; Internal medicine; Protein kinase B; Signal transduction; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001790701,0.0002971661,0.0002401709,0.0002799077,0.0001089441,0.0001951859,0.0001723525,0.0002906185,0.000778406],"category_scores_gemma":[0.0001236635,0.0001162446,0.0001760893,0.0001958388,0.00008433522,0.0001114765,0.0001555586,0.0001959676,0.0003140422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506079,"about_ca_system_score_gemma":0.0001925373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117023,"about_ca_topic_score_gemma":0.002774507,"domain_scores_codex":[0.9999044,0.00001611781,0.000006420632,0.00001651623,0.00004081901,0.00001575389],"domain_scores_gemma":[0.9999375,0.00001594408,0.00001393609,0.00000561518,0.00001308244,0.00001378678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000389653,0.00003730305,0.0001005271,0.00002898913,0.000003056892,0.00002801113,0.000006895148,0.0004564674,0.9972901,0.00001423054,0.00003936769,0.001956013],"study_design_scores_gemma":[0.00001251114,0.0005124551,0.0007975454,0.000003458919,0.000008410308,0.0000655132,0.000007496351,0.002141882,0.9953588,0.000006826873,0.001080605,0.000004566582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873733,0.001677431,0.007486162,0.00009908641,0.00001452456,0.0002015557,0.0009491251,0.0001645306,0.002034439],"genre_scores_gemma":[0.9768469,0.001223064,0.01731541,0.00006966258,0.000004829273,0.0001563865,0.0007549116,0.0000377767,0.003591107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117023,"threshold_uncertainty_score":0.002604008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1174391113757327,"score_gpt":0.3836898054415954,"score_spread":0.2662506940658627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}