{"id":"W3083359640","doi":"10.1038/s41591-020-1022-1","title":"Recommendations for measuring HIV reservoir size in cure-directed clinical trials","year":2020,"lang":"en","type":"review","venue":"Nature Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; National Institute on Drug Abuse; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institutes of Health","keywords":"Human immunodeficiency virus (HIV); Clinical trial; Medicine; Intensive care medicine; Internal medicine; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.007387362,0.000453906,0.004550118,0.0003017189,0.0001245071,0.000008619037,0.0004846551,0.002084319,0.001231641],"category_scores_gemma":[0.05357447,0.0002750918,0.0007078761,0.00058779,0.0001904231,0.00003393272,0.000107401,0.003954297,0.0005291112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001974737,"about_ca_system_score_gemma":0.0006030334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002436599,"about_ca_topic_score_gemma":0.00008498688,"domain_scores_codex":[0.9918047,0.004743397,0.002101292,0.0007204696,0.0001058715,0.0005242765],"domain_scores_gemma":[0.9797787,0.01887609,0.0006016414,0.0004599399,0.0001653671,0.0001182681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000193791,0.0001294108,0.00001500882,0.001589803,0.0009324729,0.00003439224,0.00004760653,9.651656e-9,0.000007356728,0.00005938451,0.3428366,0.6541541],"study_design_scores_gemma":[0.005145419,0.0004111482,0.00001651334,0.009175026,0.0009124972,0.00003041168,0.000025359,3.811915e-7,0.000007433955,0.00006250314,0.9840168,0.0001965233],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001857383,0.9762953,0.00001630336,0.01712987,0.001969637,0.002916259,0.0008394639,0.0001181815,0.0007131107],"genre_scores_gemma":[0.00002266586,0.9884248,0.0003233837,0.0002556187,0.0008603812,0.0006487796,0.006353448,0.0000509804,0.003059951],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6539576,"threshold_uncertainty_score":0.9999701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3179181701100541,"score_gpt":0.5210501784099167,"score_spread":0.2031320082998626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}