{"id":"W3083362003","doi":"10.1158/1538-7445.am2020-ct289","title":"Abstract CT289: Pembrolizumab plus lenvatinib vs docetaxel in patients with previously treated metastatic non-small-cell lung cancer (NSCLC) and PD after platinum-doublet chemotherapy and immunotherapy: Phase 3, randomized, open-label LEAP-008 trial","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Lenvatinib; Medicine; Pembrolizumab; Docetaxel; Internal medicine; Oncology; Chemotherapy; Tolerability; Lung cancer; Cancer; Immunotherapy; Adverse effect; Thyroid cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001364072,0.001887742,0.002369212,0.0003624325,0.0004372106,0.001370246,0.001109021,0.001586047,0.006932254],"category_scores_gemma":[0.00110703,0.0006424216,0.002072545,0.0004047903,0.0009905311,0.001203522,0.0004769128,0.00407814,0.001508719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00110304,"about_ca_system_score_gemma":0.001326379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001482784,"about_ca_topic_score_gemma":0.00369652,"domain_scores_codex":[0.9995467,0.0002310343,0.00002508541,0.00008963064,0.00003799434,0.0000694066],"domain_scores_gemma":[0.9992877,0.0001270413,0.0001541953,0.00004443222,0.00003672571,0.0003500609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9816828,0.004144463,0.0008365596,0.0003163074,0.0008747414,0.00004233688,0.00003035269,0.0004054165,0.002360827,0.00008787954,0.001564293,0.007654011],"study_design_scores_gemma":[0.9451938,0.04984624,0.002728458,0.00002853128,0.0004856141,0.00004272042,0.00001895107,0.0004998271,0.0003243885,0.0001782493,0.0006398105,0.00001333654],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848282,0.004231699,0.0004000271,0.001327947,0.0006118952,0.002673956,0.002525979,0.0001497125,0.003250553],"genre_scores_gemma":[0.9864886,0.001735187,0.000723899,0.001426238,0.0004064748,0.002226038,0.002608921,0.0000284184,0.004356177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006932254,"threshold_uncertainty_score":0.02319074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06063151066195843,"score_gpt":0.3827579354018186,"score_spread":0.3221264247398601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}