{"id":"W3083376441","doi":"10.1158/1538-7445.am2020-1008","title":"Abstract 1008: Characterizing the post-translational regulation of programmed death-ligand 1 (PD-L1) in triple-negative breast cancer: Role of EphA3/Fes/Fer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Receptor tyrosine kinase; Cancer research; Triple-negative breast cancer; Immune checkpoint; Immunotherapy; Kinase; Cancer immunotherapy; PD-L1; Cancer; Immune system; Tyrosine kinase; Biology; Downregulation and upregulation; Cancer cell; Breast cancer; Cell biology; Signal transduction; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001029267,0.0002865977,0.0002573958,0.000247414,0.0001627086,0.0002367007,0.0001648284,0.0002617195,0.001381973],"category_scores_gemma":[0.00009626209,0.00007805407,0.0002968691,0.000199973,0.0001072894,0.0001469818,0.0001327041,0.0003444804,0.000572363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002964366,"about_ca_system_score_gemma":0.000167155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004394682,"about_ca_topic_score_gemma":0.0006105877,"domain_scores_codex":[0.99994,0.000004853797,0.000004916617,0.00001471638,0.00001889944,0.00001655227],"domain_scores_gemma":[0.9999517,0.000006741429,0.00001249982,0.0000031391,0.00001065058,0.00001528246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001905644,0.00002648983,0.001094592,0.00007328887,0.000008524198,0.000153562,0.00001165642,0.000054286,0.9969302,0.00002393385,0.00007214794,0.001360711],"study_design_scores_gemma":[0.0000260885,0.0004375136,0.04223761,0.0000134822,0.00006052409,0.002280915,0.00006816649,0.001748053,0.9491913,0.00006993071,0.003855956,0.00001033711],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994881,0.002054994,0.001141443,0.00009703952,0.0000202083,0.00002439879,0.0008297619,0.00002919112,0.0009219559],"genre_scores_gemma":[0.989206,0.001206243,0.003195656,0.0001012641,0.00001497744,0.00003320472,0.003023564,0.00001504224,0.003204083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381973,"threshold_uncertainty_score":0.004623115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07469745203307526,"score_gpt":0.3756242298276642,"score_spread":0.300926777794589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}