{"id":"W3083419119","doi":"10.1158/1538-7445.am2020-1869","title":"Abstract 1869: Methylation signatures associated with T790M status in progressive NSCLC","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"","keywords":"T790M; Medicine; DNA methylation; Oncology; Methylation; Internal medicine; Bioinformatics; Cancer; Biology; Genetics; DNA; Adenocarcinoma; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421135,0.0001244142,0.0002141665,0.0003436912,0.0001661804,0.0002017107,0.000102334,0.0001866755,0.00205381],"category_scores_gemma":[0.0004016288,0.00007716053,0.0001071358,0.0004245158,0.0001348063,0.00008225381,0.0001826537,0.0001613703,0.0004517245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001457833,"about_ca_system_score_gemma":0.0001380607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006669,"about_ca_topic_score_gemma":0.00126757,"domain_scores_codex":[0.9999038,0.00001304778,0.000007805498,0.00003276468,0.00002522392,0.00001737771],"domain_scores_gemma":[0.9998879,0.00002714313,0.00003689089,0.0000101655,0.00002009959,0.00001780235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002841003,0.00007491204,0.5216842,0.0001329774,0.00009132035,0.0003223041,0.0002020208,0.0008002495,0.4464829,0.00007797914,0.0006717423,0.02661845],"study_design_scores_gemma":[0.00002053613,0.0002353901,0.9799503,0.000004147512,0.00004442362,0.000811877,0.00006268762,0.001055888,0.01688259,0.00009935365,0.0008271709,0.000005582355],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997667,0.0002280641,0.0005059892,0.00002307343,0.000002393541,0.00001017242,0.001075133,0.00001857533,0.0004697816],"genre_scores_gemma":[0.9980305,0.00007070605,0.0004615474,0.00001389266,0.00000417105,0.00001517622,0.0009676208,0.000008415642,0.0004280234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205381,"threshold_uncertainty_score":0.006870627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07790474931393125,"score_gpt":0.4618267536533595,"score_spread":0.3839220043394282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}