{"id":"W3083421916","doi":"10.1089/gen.40.09.04","title":"Gene Therapy: It Is Time to Talk about High-Dose AAV","year":2020,"lang":"en","type":"article","venue":"Genetic Engineering & Biotechnology News","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saint Paul University","funders":"","keywords":"Genetic enhancement; Adeno-associated virus; Gene; Library science; Gene transfer; Medicine; Vector (molecular biology); Biology; Genetics; Computer science; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00299958,0.0006933404,0.0005336722,0.0004854028,0.001076151,0.003228879,0.0005606635,0.004552516,0.01776989],"category_scores_gemma":[0.00329564,0.0002621736,0.0007459184,0.0003183381,0.001507113,0.003559893,0.0008129299,0.01008037,0.006468366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001231067,"about_ca_system_score_gemma":0.001063837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001345699,"about_ca_topic_score_gemma":0.002214127,"domain_scores_codex":[0.9988883,0.0001746333,0.00005641043,0.0001178935,0.0006537734,0.0001089594],"domain_scores_gemma":[0.9978778,0.0007078868,0.00017702,0.0001209201,0.0005674791,0.0005489546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003183502,0.0001145606,0.0004550498,0.0003620066,0.00004290974,0.0002722069,0.000145651,0.00007269328,0.01565306,0.01056986,0.8622826,0.1097111],"study_design_scores_gemma":[0.00003575249,0.0001180841,0.0005708795,0.00008070913,0.00001562787,0.0003743187,0.0000946315,0.00005236579,0.004248146,0.001959614,0.9924271,0.00002288227],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003626397,0.1013715,0.00930832,0.672436,0.1629844,0.0001144618,0.0003338402,0.001208627,0.04861654],"genre_scores_gemma":[0.0273287,0.05312404,0.00882529,0.4925463,0.06456553,0.0001610828,0.0006602702,0.0008197127,0.3519691],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01776989,"threshold_uncertainty_score":0.05944628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024967491101038,"score_gpt":0.2370388881554522,"score_spread":0.2267892132444418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}