{"id":"W3083421916","doi":"10.1089/gen.40.09.04","title":"Gene Therapy: It Is Time to Talk about High-Dose AAV","year":2020,"lang":"en","type":"article","venue":"Genetic Engineering & Biotechnology News","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saint Paul University","funders":"","keywords":"Genetic enhancement; Adeno-associated virus; Gene; Library science; Gene transfer; Medicine; Vector (molecular biology); Biology; Genetics; Computer science; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001119905,0.0003973033,0.0003348858,0.0001750397,0.00007247927,0.00003522871,0.0008533402,0.0006561047,0.0004982527],"category_scores_gemma":[0.00009839955,0.000416198,0.0001332554,0.0005029373,0.00009216316,0.000003381461,0.0003595669,0.0003409745,0.0009963678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002934478,"about_ca_system_score_gemma":0.00009251786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001679099,"about_ca_topic_score_gemma":0.00001128431,"domain_scores_codex":[0.9978198,0.00003777573,0.0003366801,0.0008591008,0.0002283535,0.0007183328],"domain_scores_gemma":[0.9986178,0.00001102393,0.00005580937,0.0009434798,0.00006469811,0.0003071335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003383025,0.00003197579,0.00001866015,0.00001143249,0.0001196126,0.00002736238,0.00004832048,0.003129705,0.9550771,0.00000286693,0.01368914,0.02750557],"study_design_scores_gemma":[0.0007142553,0.002387069,0.0001649019,0.000007519625,0.000008701894,0.00002428921,0.000007857444,0.0007482528,0.7945178,0.000007660333,0.2010458,0.0003659424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606377,0.004032622,0.005255783,0.02895446,0.0001212942,0.0006097732,0.00005548098,0.0002587326,0.00007416892],"genre_scores_gemma":[0.945143,0.004355827,0.02225343,0.02512835,0.001029587,0.0002295078,0.0001273503,0.0003052539,0.001427688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1873567,"threshold_uncertainty_score":0.999829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024967491101038,"score_gpt":0.2370388881554522,"score_spread":0.2267892132444418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}