{"id":"W3083440288","doi":"10.1158/1538-7445.am2020-ct272","title":"Abstract CT272: Phase 2 study of dianhydrogalactitol (VAL-083) in patients with MGMT-unmethylated, bevacizumab-naïve glioblastoma in the recurrent or adjuvant setting","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada)","funders":"","keywords":"Temozolomide; Bevacizumab; Medicine; Oncology; Internal medicine; Adjuvant; Adjuvant therapy; Phases of clinical research; Cancer; Radiation therapy; Cancer research; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009255793,0.0018006,0.00155108,0.000429904,0.000418974,0.0009447671,0.0008846712,0.001171412,0.003411694],"category_scores_gemma":[0.0005145442,0.0005826292,0.001051023,0.0004288757,0.0009134249,0.0006789273,0.0003425326,0.002959978,0.001056343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00130836,"about_ca_system_score_gemma":0.002215207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002390425,"about_ca_topic_score_gemma":0.005262155,"domain_scores_codex":[0.9997401,0.00009560614,0.00001002418,0.0000539132,0.00002431013,0.0000761247],"domain_scores_gemma":[0.9996378,0.00002709289,0.0000421537,0.00002417767,0.0000256315,0.0002431162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.715961,0.1108037,0.008051528,0.0007597021,0.001294239,0.0004902324,0.0003880294,0.002526234,0.07621866,0.0004204853,0.007449212,0.07563698],"study_design_scores_gemma":[0.4354848,0.5477701,0.007891452,0.00002813364,0.0003534858,0.0002415822,0.00007801539,0.001113861,0.00442129,0.0002035765,0.002376989,0.00003662769],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930611,0.001145058,0.0003462608,0.0004651976,0.0001032141,0.002327132,0.001089192,0.0001042848,0.001358443],"genre_scores_gemma":[0.9871812,0.00148856,0.001028631,0.00090351,0.0001315138,0.002758772,0.003065845,0.00003882882,0.003403143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003411694,"threshold_uncertainty_score":0.01141322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07203583874636765,"score_gpt":0.4184064016721624,"score_spread":0.3463705629257948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}