{"id":"W3083449611","doi":"10.3390/genes11091055","title":"LAMB3 Missense Variant in Australian Shepherd Dogs with Junctional Epidermolysis Bullosa","year":2020,"lang":"en","type":"article","venue":"Genes","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"University of Bern","keywords":"Junctional epidermolysis bullosa (veterinary medicine); Epidermolysis bullosa; Biology; Genetics; Missense mutation; Dermis; Candidate gene; Allele; Pathology; Phenotype; Gene; Medicine; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283367,0.000132367,0.0001376399,0.00002930465,0.00005139678,0.00001601155,0.0001466617,0.000144215,0.0002170785],"category_scores_gemma":[0.0000465418,0.0001071938,0.00006071986,0.0001528147,0.00009619173,0.000001943015,0.00007035318,0.00010209,0.00005522352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006119303,"about_ca_system_score_gemma":0.00009747098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008714874,"about_ca_topic_score_gemma":0.00007763455,"domain_scores_codex":[0.9989945,0.00009365052,0.0001413424,0.0003848449,0.0001155961,0.000270011],"domain_scores_gemma":[0.9995874,0.0000107222,0.00002892068,0.0001931684,0.00005133996,0.0001284815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006359349,0.00009507022,0.01508866,0.00002868821,0.0001606064,0.003441665,0.00008841342,0.0001689474,0.9698104,0.0001051451,0.005589361,0.004787065],"study_design_scores_gemma":[0.004080056,0.001855259,0.01876798,0.00003336641,0.0000853958,0.007471858,0.0006954503,0.0004036927,0.6844011,0.000155632,0.2809477,0.001102516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940747,0.0009324285,0.000373103,0.003780832,0.00005216142,0.0001232722,0.00001198856,0.00001180478,0.0006396824],"genre_scores_gemma":[0.9963129,0.0001817177,0.0007078922,0.0004123877,0.0003178817,0.00002164735,0.0001698046,0.00001748358,0.001858241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2854094,"threshold_uncertainty_score":0.4371237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192745902410891,"score_gpt":0.2581722268719311,"score_spread":0.2362447678478222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}