{"id":"W3083449611","doi":"10.3390/genes11091055","title":"LAMB3 Missense Variant in Australian Shepherd Dogs with Junctional Epidermolysis Bullosa","year":2020,"lang":"en","type":"article","venue":"Genes","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"University of Bern","keywords":"Junctional epidermolysis bullosa (veterinary medicine); Epidermolysis bullosa; Biology; Genetics; Missense mutation; Dermis; Candidate gene; Allele; Pathology; Phenotype; Gene; Medicine; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002108587,0.0004436765,0.0003408463,0.00112221,0.0006151382,0.0003398849,0.0003738585,0.0008971406,0.001250754],"category_scores_gemma":[0.0007125458,0.0002625743,0.0004299573,0.0006907301,0.0008349674,0.0001641928,0.0005110467,0.0003814979,0.0001860854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003975004,"about_ca_system_score_gemma":0.0001756685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006063738,"about_ca_topic_score_gemma":0.007217315,"domain_scores_codex":[0.9996904,0.00003454481,0.00002856168,0.00009547066,0.0001026106,0.0000484414],"domain_scores_gemma":[0.9997359,0.00006407095,0.00008864418,0.00002022712,0.00002543358,0.00006578636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001146203,0.0005161993,0.434323,0.0002598351,0.0003666993,0.3254767,0.008141761,0.0005207066,0.2120849,0.0003763089,0.0006735738,0.01611407],"study_design_scores_gemma":[0.00004983978,0.0005104587,0.8708917,0.0000280015,0.0001892557,0.1190924,0.0008968958,0.0007924466,0.006170509,0.0001406516,0.001209239,0.00002853495],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996778,0.00004448396,0.00006651672,0.00001319463,0.000002003935,0.000004947411,0.00003124359,0.000004859935,0.0001551006],"genre_scores_gemma":[0.9995317,0.00005108901,0.0001153059,0.00002180143,0.000003634573,0.000002965375,0.00006452341,0.00000291426,0.0002059708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006063738,"threshold_uncertainty_score":0.01205689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192745902410891,"score_gpt":0.2581722268719311,"score_spread":0.2362447678478222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}