{"id":"W3083470695","doi":"10.1158/1538-7445.am2020-4550","title":"Abstract 4550: Increased IL-27 is associated with poor prognosis in renal cell carcinoma and supports use of SRF388, a first-in-class IL-27p28 blocking antibody, to counteract IL-27-mediated immunosuppression in this setting","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Glycoprotein 130; Cancer research; Cytokine; Antibody; Immune system; Biology; Immunology; Medicine; Interleukin 6","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001831415,0.0001547675,0.0002458683,0.0004014827,0.000203864,0.0002113174,0.0001925799,0.0002257523,0.00484558],"category_scores_gemma":[0.0002402126,0.00007733879,0.0002184159,0.0003802539,0.0001507261,0.00008404676,0.0001281998,0.0003646173,0.0007149493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000245202,"about_ca_system_score_gemma":0.0003198244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007986284,"about_ca_topic_score_gemma":0.00117822,"domain_scores_codex":[0.9999276,0.00001364573,0.000004511483,0.00001817063,0.00002167717,0.00001429485],"domain_scores_gemma":[0.9998205,0.00002531488,0.00005338048,0.00001352978,0.00002967715,0.00005759231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005962603,0.000396787,0.6355251,0.000385113,0.0003374916,0.001718026,0.00006583291,0.0004809333,0.3092407,0.0002406784,0.0051137,0.04053307],"study_design_scores_gemma":[0.0001227475,0.0006277162,0.9551648,0.0000182717,0.0001819258,0.00292036,0.00005256425,0.0007678947,0.03479902,0.0001713211,0.005163879,0.000009359725],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908825,0.002894913,0.0009996732,0.000434961,0.00005062892,0.00003698612,0.001720508,0.0001375411,0.002842267],"genre_scores_gemma":[0.9963086,0.0004557821,0.0006219759,0.00008670189,0.00003634368,0.00002317055,0.001471132,0.00001346802,0.0009827708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00484558,"threshold_uncertainty_score":0.01621014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04198249141507971,"score_gpt":0.3361593111368219,"score_spread":0.2941768197217422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}