{"id":"W3083505424","doi":"10.1111/febs.15553","title":"The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress","year":2020,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Fondation ARC pour la Recherche sur le Cancer; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Proteostasis; Integrated stress response; Cell biology; Biology; eIF2; ATF4; Innate immune system; Proteotoxicity; Stress granule; HSF1; Kinase; Unfolded protein response; Protein kinase R; Translation (biology); Protein kinase A; Heat shock protein; Biochemistry; Genetics; Endoplasmic reticulum; Protein aggregation; Cyclin-dependent kinase 2; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001976262,0.0003502552,0.0005924812,0.00006359552,0.0002759739,0.0002706131,0.0004725135,0.0002639601,0.00001247886],"category_scores_gemma":[0.0003438541,0.00022221,0.000311655,0.0001207205,0.0001246333,0.000005279285,0.000349675,0.0008159186,0.000006839998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003011977,"about_ca_system_score_gemma":0.000445559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000011586,"about_ca_topic_score_gemma":0.00003946733,"domain_scores_codex":[0.9981289,0.0004475535,0.0005616671,0.0003153252,0.0002014367,0.0003451261],"domain_scores_gemma":[0.9989263,0.00004922952,0.0003695803,0.0003362204,0.00005551401,0.0002631083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001655203,0.0001181228,0.00009395321,0.00223667,0.0002658203,0.0004530315,0.00004079867,0.000001626655,0.0001126726,0.00006627406,0.00473628,0.9917092],"study_design_scores_gemma":[0.0005927027,0.0001399579,0.00001897792,0.002250605,0.0001571673,0.0003273933,0.00005066619,0.000002575527,0.0001196101,0.00004824634,0.9960227,0.0002693846],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007229631,0.9977718,0.00001547661,0.0001759019,0.0004242068,0.0005164889,0.0001504643,0.000004439913,0.0002182665],"genre_scores_gemma":[0.0004240184,0.9981885,0.00008559269,0.00004506878,0.000919035,0.00007001343,0.0001191336,0.00004087662,0.0001077899],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9914398,"threshold_uncertainty_score":0.9061461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751576805693432,"score_gpt":0.3019169090807939,"score_spread":0.2844011410238596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}