{"id":"W3083505424","doi":"10.1111/febs.15553","title":"The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress","year":2020,"lang":"en","type":"review","venue":"FEBS Journal","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Fondation ARC pour la Recherche sur le Cancer; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Proteostasis; Integrated stress response; Cell biology; Biology; eIF2; ATF4; Innate immune system; Proteotoxicity; Stress granule; HSF1; Kinase; Unfolded protein response; Protein kinase R; Translation (biology); Protein kinase A; Heat shock protein; Biochemistry; Genetics; Endoplasmic reticulum; Protein aggregation; Cyclin-dependent kinase 2; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004481667,0.001004738,0.0009495409,0.002393516,0.0003350954,0.0008515506,0.0007621141,0.0009252765,0.00259527],"category_scores_gemma":[0.0004399926,0.0002560487,0.0003090859,0.002553853,0.0004503967,0.001462711,0.000724322,0.001673521,0.002782114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006566919,"about_ca_system_score_gemma":0.000957548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00067408,"about_ca_topic_score_gemma":0.001156497,"domain_scores_codex":[0.9998808,0.00001596348,0.00001812669,0.00002143418,0.00004845197,0.00001532133],"domain_scores_gemma":[0.9998228,0.00005718252,0.00002476198,0.000006926846,0.00005337363,0.00003499043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008321677,0.00006716649,0.0001395422,0.01124043,0.00005830325,0.0002423831,0.00006573992,0.0004076036,0.002954892,0.004654309,0.04483844,0.9352479],"study_design_scores_gemma":[0.00001016981,0.00007247653,0.0005846116,0.001402169,0.00004739367,0.0008534524,0.00003663871,0.00006269015,0.0003808539,0.001587883,0.9949497,0.00001201159],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001074497,0.9978314,0.0001397427,0.000222193,0.0004353325,0.000003629802,0.00001294181,0.00001088347,0.001236362],"genre_scores_gemma":[0.0005768032,0.9980106,0.0001854815,0.0001398457,0.0002681308,0.000005094895,0.00002891668,0.000001802514,0.0007832868],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00259527,"threshold_uncertainty_score":0.008682072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751576805693432,"score_gpt":0.3019169090807939,"score_spread":0.2844011410238596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}