{"id":"W3083529384","doi":"10.3389/fimmu.2020.01929","title":"A Race Against Time—Changing the Natural History of CRIM Negative Infantile Pompe Disease","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lysosomal Disease Network; National Institutes of Health; Rare Diseases Clinical Research Network","keywords":"Medicine; Enzyme replacement therapy; Left ventricular hypertrophy; Pediatrics; Internal medicine; Rituximab; Cardiology; Disease; Surgery; Antibody; Immunology; Blood pressure","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001593086,0.0002842997,0.0001276075,0.0002351112,0.0008606825,0.0002912848,0.0002731601,0.0005458858,0.001758885],"category_scores_gemma":[0.0005124088,0.00006149348,0.0001684176,0.0001846361,0.0002398686,0.0003022389,0.0001787465,0.0005066992,0.0002797412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002981298,"about_ca_system_score_gemma":0.0002779178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002477704,"about_ca_topic_score_gemma":0.003697953,"domain_scores_codex":[0.9998816,0.00002605408,0.0000081034,0.00003887133,0.00001525663,0.00003008514],"domain_scores_gemma":[0.9998957,0.00001465185,0.00002530389,0.000006329594,0.00001026438,0.00004773914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002071975,0.001481128,0.5973589,0.0001024038,0.000123028,0.2035737,0.0009082902,0.0004464176,0.03184088,0.004136212,0.01283532,0.1451216],"study_design_scores_gemma":[0.0001843523,0.003214851,0.6211805,0.0002717293,0.0001140535,0.3220417,0.00124823,0.001714352,0.003120536,0.001951628,0.04489418,0.00006391903],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832276,0.0009884327,0.0003718347,0.003656662,0.0002011442,0.00004442035,0.000222858,0.00003557416,0.01125147],"genre_scores_gemma":[0.994333,0.0003661249,0.0005938115,0.001632425,0.0000780239,0.00001737538,0.0001393694,0.000009547165,0.002830314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002477704,"threshold_uncertainty_score":0.005883992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01175719214191409,"score_gpt":0.2478150227782266,"score_spread":0.2360578306363125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}