{"id":"W3083529479","doi":"10.1158/1538-7445.am2020-5853","title":"Abstract 5853: Identification of <i>TSC1</i> and <i>TSC2</i> as potential determinants of sensitivity to trastuzumab emtansine","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Genomics","funders":"","keywords":"Trastuzumab emtansine; CRISPR; Biology; Computational biology; Gene; Cas9; Trastuzumab; Genetics; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006931068,0.0002353736,0.0002693705,0.0003099343,0.000108876,0.0002192588,0.0001679628,0.0001926548,0.002194117],"category_scores_gemma":[0.0001669556,0.00008386438,0.0002246998,0.0002052461,0.0001236064,0.00006978853,0.0001078183,0.0002143547,0.0005975702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000227209,"about_ca_system_score_gemma":0.0001181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00160245,"about_ca_topic_score_gemma":0.001105761,"domain_scores_codex":[0.9998933,0.000008402965,0.000008962568,0.00002831204,0.00003675098,0.00002432114],"domain_scores_gemma":[0.9999059,0.00001952756,0.00003253738,0.000006326014,0.0000134087,0.00002235905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009303021,0.00001321095,0.001128761,0.00001094189,0.000004195678,0.00004818268,0.000005469515,0.00005693221,0.9976833,0.00002301963,0.00005299256,0.0008800375],"study_design_scores_gemma":[0.00001691301,0.0002070861,0.08121243,0.000006276241,0.00003473547,0.0006868076,0.00003865628,0.002409738,0.9132249,0.00005377784,0.002099766,0.000008981627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952186,0.0003598351,0.001500012,0.0000561068,0.000009788955,0.00002552609,0.001702736,0.00006123713,0.001066081],"genre_scores_gemma":[0.9942497,0.0001688072,0.001414029,0.00004987985,0.000005182078,0.00002212613,0.002471012,0.0000325532,0.001586725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002194117,"threshold_uncertainty_score":0.007340014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07742955374148075,"score_gpt":0.4238078533292968,"score_spread":0.346378299587816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}