{"id":"W3083560784","doi":"10.1016/j.vaccine.2020.08.066","title":"A bivalent HCV peptide vaccine elicits pan-genotypic neutralizing antibodies in mice","year":2020,"lang":"en","type":"article","venue":"Vaccine","topic":"Hepatitis C virus research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Immunogen; Epitope; Virology; Hypervariable region; Biology; Antibody; Neutralization; Bivalent (engine); Neutralizing antibody; Monoclonal antibody; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004985352,0.001130007,0.0004820868,0.0008607145,0.0002866892,0.0005229227,0.0004180833,0.0009795793,0.001551279],"category_scores_gemma":[0.0002571594,0.0004922973,0.0003970582,0.0001911672,0.0004741225,0.0005990012,0.000297647,0.00247447,0.0006196875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004909287,"about_ca_system_score_gemma":0.0003883335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008198559,"about_ca_topic_score_gemma":0.0008763963,"domain_scores_codex":[0.9996238,0.000049309,0.00002708068,0.00009736052,0.00005345346,0.0001489463],"domain_scores_gemma":[0.9996848,0.00005570305,0.0000760718,0.00004534183,0.00004063025,0.00009754621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001206487,0.0005650682,0.000289442,0.00006692757,0.00001831258,0.00008192359,0.00004464332,0.0004096965,0.9937263,0.0003976658,0.0002458229,0.002947714],"study_design_scores_gemma":[0.0007830946,0.008369284,0.00409206,0.00004045504,0.000121182,0.0006419146,0.00009157001,0.005197471,0.9755428,0.0004804705,0.004611766,0.00002785328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896976,0.0007747593,0.004470607,0.0004077586,0.0002142016,0.0001584557,0.0006471184,0.0003230558,0.003306461],"genre_scores_gemma":[0.9901016,0.0007201314,0.002111659,0.0003503578,0.00008276608,0.0001408606,0.0005552912,0.00005677698,0.005880572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001551279,"threshold_uncertainty_score":0.005189538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05072426173268774,"score_gpt":0.3271521102256473,"score_spread":0.2764278484929595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}