{"id":"W3083563724","doi":"10.1158/1538-7445.am2020-lb-397","title":"Abstract LB-397: Pembrolizumab plus pemetrexed and platinum vs placebo plus pemetrexed and platinum as first-line therapy for metastatic nonsquamous NSCLC: analysis of KEYNOTE-189 by <i>STK11</i> and <i>KEAP1</i> status","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Pembrolizumab; Pemetrexed; STK11; Medicine; Internal medicine; Oncology; Gemcitabine; Chemotherapy; Cancer; Immunotherapy; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005650861,0.0003779582,0.0007781403,0.0002603532,0.0002765425,0.0001475741,0.000263951,0.0001908728,0.00009772724],"category_scores_gemma":[0.0006635179,0.000364158,0.0001579472,0.0006991816,0.0004281594,0.00001839982,0.0002985935,0.0003201191,0.000001501837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001153233,"about_ca_system_score_gemma":0.0006529159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002006626,"about_ca_topic_score_gemma":0.001831376,"domain_scores_codex":[0.9971394,0.0001015529,0.0005437573,0.0009547641,0.0004903767,0.0007701768],"domain_scores_gemma":[0.9976904,0.0007621823,0.0002237595,0.0004200944,0.0003832215,0.0005203417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04955347,0.0004323591,0.01031192,0.001662672,0.00559349,0.00005221693,0.004533432,0.005404396,0.8390768,0.0002127307,0.03936822,0.04379835],"study_design_scores_gemma":[0.09577822,0.01487388,0.01782782,0.0002936649,0.002880549,0.000036649,0.003787,0.03715245,0.5901976,0.0006054846,0.2330587,0.003507986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688736,0.0246588,0.0005530246,0.001179908,0.00006168117,0.001385007,0.003025338,0.00001419564,0.0002484924],"genre_scores_gemma":[0.9736988,0.02400096,0.0003908761,0.0005265675,0.0001694944,0.0003255733,0.0005969397,0.00007329063,0.0002174824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2488791,"threshold_uncertainty_score":0.999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04591521209032755,"score_gpt":0.3512563928102844,"score_spread":0.3053411807199568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}