{"id":"W3083563724","doi":"10.1158/1538-7445.am2020-lb-397","title":"Abstract LB-397: Pembrolizumab plus pemetrexed and platinum vs placebo plus pemetrexed and platinum as first-line therapy for metastatic nonsquamous NSCLC: analysis of KEYNOTE-189 by <i>STK11</i> and <i>KEAP1</i> status","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Pembrolizumab; Pemetrexed; STK11; Medicine; Internal medicine; Oncology; Gemcitabine; Chemotherapy; Cancer; Immunotherapy; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006806491,0.0004788949,0.001651249,0.0002247024,0.0001561194,0.0006010277,0.0004508119,0.0005683218,0.004399931],"category_scores_gemma":[0.0008311012,0.0002118199,0.0009821315,0.0002231875,0.0003154793,0.0005180049,0.0002646544,0.001397807,0.0005636839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006071728,"about_ca_system_score_gemma":0.0005263614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004823922,"about_ca_topic_score_gemma":0.0008325014,"domain_scores_codex":[0.9996293,0.0001334039,0.00004383454,0.00008014447,0.0000535556,0.00005984807],"domain_scores_gemma":[0.9996127,0.0001033138,0.0000891275,0.0000264874,0.00001836525,0.0001499662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9307951,0.005166287,0.00651452,0.0003979157,0.001748642,0.00006836488,0.00004708181,0.0006160172,0.0182084,0.00009362184,0.00103886,0.03530506],"study_design_scores_gemma":[0.3361332,0.5092044,0.1255814,0.0001800937,0.005582376,0.0005281793,0.0001723425,0.004954832,0.01306802,0.000450895,0.00407273,0.00007138979],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972047,0.001151809,0.00009090481,0.000127874,0.00006977016,0.0001380887,0.0004937111,0.00002305179,0.00070008],"genre_scores_gemma":[0.9978006,0.0003531197,0.000151653,0.0001204222,0.00005455989,0.0001361604,0.0006638222,0.000005255189,0.0007143182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004399931,"threshold_uncertainty_score":0.01471919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04591521209032755,"score_gpt":0.3512563928102844,"score_spread":0.3053411807199568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}