{"id":"W3083572265","doi":"10.1093/nar/gkaa718","title":"Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Poly ADP ribose polymerase; In vivo; DNA damage; PARP1; DNA; Genetics; Molecular biology; Cell biology; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.002829547,0.0002819854,0.0006660973,0.0003536419,0.000214935,0.00007358285,0.0004267864,0.0003845099,0.009485518],"category_scores_gemma":[0.001023047,0.0002615499,0.0002295583,0.001339723,0.0007467413,0.0001970362,0.0005446098,0.001662537,0.002028546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005073238,"about_ca_system_score_gemma":0.0002526123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004790309,"about_ca_topic_score_gemma":0.00005113123,"domain_scores_codex":[0.9946899,0.0008039111,0.0008708714,0.0009426871,0.001669237,0.001023373],"domain_scores_gemma":[0.9972714,0.0007001229,0.0001074499,0.0007542371,0.0003161291,0.00085065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003310709,0.0005642092,0.3716394,0.0004785981,0.0001110354,0.001007689,0.003976958,0.000004660354,0.30054,0.0001978485,0.305848,0.01232096],"study_design_scores_gemma":[0.01387953,0.002981625,0.09021466,0.0006684817,0.00003603485,0.00003869735,0.001261821,0.001291548,0.1773807,0.0002832037,0.7112864,0.0006773288],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610022,0.0004713953,0.00000895038,0.0196947,0.0002013475,0.0009524665,0.00006820222,0.0001630433,0.0174377],"genre_scores_gemma":[0.9899832,0.001208881,0.0003791537,0.003976393,0.001924797,0.0001442812,0.00003175829,0.0001017065,0.002249834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4054384,"threshold_uncertainty_score":0.9999837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1742744614439555,"score_gpt":0.4446949844921173,"score_spread":0.2704205230481618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}