{"id":"W3083579627","doi":"10.1158/1538-7445.am2020-lb-307","title":"Abstract LB-307: Translational and mechanistic implications of osteosarcoma genomics: A TARGET report","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"CDKN2A; PDGFRA; Biology; PTEN; Transcriptome; Cancer research; Copy-number variation; Synthetic lethality; Cancer; Genome instability; DNA methylation; ARID1A; Targeted therapy; Genetics; Gene; Mutation; Genome; DNA repair; Gene expression; DNA damage; DNA; PI3K/AKT/mTOR pathway; Stromal cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006216594,0.0003706796,0.0004883136,0.0003880842,0.0003122879,0.001175656,0.0003964835,0.0006456563,0.005292639],"category_scores_gemma":[0.0003203328,0.000153879,0.0003075243,0.0006947751,0.0003190442,0.0005216783,0.0004968892,0.0007190343,0.002013012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008526382,"about_ca_system_score_gemma":0.0007461268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008055806,"about_ca_topic_score_gemma":0.0008040128,"domain_scores_codex":[0.9998453,0.00002708136,0.000007388256,0.00003563823,0.00005092129,0.00003365069],"domain_scores_gemma":[0.9997706,0.00004520562,0.00003724685,0.00002115411,0.00005613297,0.00006959768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00222139,0.0005050639,0.01351099,0.001037207,0.00007286097,0.001622368,0.0002505337,0.001236475,0.818325,0.008293528,0.02371549,0.1292091],"study_design_scores_gemma":[0.0006081111,0.003978468,0.1348296,0.0004633931,0.0005348523,0.008912217,0.001167952,0.01533673,0.5415678,0.01939847,0.2730857,0.0001167387],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8186694,0.05988105,0.02256609,0.02582181,0.0007881813,0.0003947732,0.01375998,0.001917773,0.05620101],"genre_scores_gemma":[0.9271871,0.01927411,0.01392741,0.002957038,0.000494094,0.0001648224,0.01624423,0.0002212367,0.01952999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005292639,"threshold_uncertainty_score":0.01770562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05930441921192003,"score_gpt":0.3658195407416472,"score_spread":0.3065151215297272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}