{"id":"W3083581581","doi":"10.1093/ije/dyab203","title":"Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease","year":2021,"lang":"en","type":"article","venue":"International Journal of Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Norwegian Institute of Public Health; Faculty of Medicine and Health, University of Sydney; Major Research Plan; Wellcome Trust; Cancer Research UK; Biotechnology and Biological Sciences Research Council; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; National Institutes of Health; Kadoorie Charitable Foundation; Medical Research Council; Recruitment Program of Global Experts; National Natural Science Foundation of China; Helse Midt-Norge; National Institute on Minority Health and Health Disparities; Japan Agency for Medical Research and Development; Deutsche Forschungsgemeinschaft; University of Bristol; Diabetes UK; National Institute for Health and Care Research; Peking University; Academy of Medical Sciences; University Hospitals Bristol NHS Foundation Trust; British Heart Foundation; China Scholarship Council; National Institute of Diabetes and Digestive and Kidney Diseases; Peking University Health Science Center; Norges Teknisk-Naturvitenskapelige Universitet; University of Michigan","keywords":"Mendelian randomization; Kidney disease; Medicine; Ethnic group; Disease; Causality (physics); Causal inference; Internal medicine; Genetics; Biology; Genetic variants; Gene; Pathology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.003447196,0.0001878924,0.0006612027,0.000180414,0.00009344822,0.00001192889,0.0002545772,0.0002089828,0.00004889223],"category_scores_gemma":[0.01636858,0.0001596843,0.0002502374,0.0001339615,0.0001020161,0.00001504553,0.00009429862,0.0003003762,0.000001973121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007732488,"about_ca_system_score_gemma":0.0003924626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002179734,"about_ca_topic_score_gemma":0.0000441677,"domain_scores_codex":[0.9955129,0.002574426,0.001131154,0.0003343707,0.0001816583,0.0002654624],"domain_scores_gemma":[0.9971983,0.0009201284,0.0006701859,0.000221514,0.0006446448,0.0003451722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001172311,0.00008144509,0.9897119,0.000005795925,0.0009278661,0.00001758027,0.0001131672,0.0009114027,0.004060972,0.000160001,0.00193973,0.001952858],"study_design_scores_gemma":[0.002524075,0.0002372091,0.9834257,0.00002093674,0.0002571959,0.0000549665,0.0002409937,0.0000667717,0.000169751,0.002080865,0.0107638,0.0001577851],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9653801,0.006270146,0.02353203,0.003663124,0.0008080573,0.0001559989,0.0001160314,0.000005281014,0.00006920986],"genre_scores_gemma":[0.9940969,0.002458452,0.001247112,0.0004245708,0.001191995,0.000008962889,0.0003956592,0.00001797262,0.0001584283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02871673,"threshold_uncertainty_score":0.991917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0679534491980617,"score_gpt":0.3595689741330856,"score_spread":0.291615524935024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}