{"id":"W3083581581","doi":"10.1093/ije/dyab203","title":"Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease","year":2021,"lang":"en","type":"article","venue":"International Journal of Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Norwegian Institute of Public Health; Faculty of Medicine and Health, University of Sydney; Major Research Plan; Wellcome Trust; Cancer Research UK; Biotechnology and Biological Sciences Research Council; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; National Institutes of Health; Kadoorie Charitable Foundation; Medical Research Council; Recruitment Program of Global Experts; National Natural Science Foundation of China; Helse Midt-Norge; National Institute on Minority Health and Health Disparities; Japan Agency for Medical Research and Development; Deutsche Forschungsgemeinschaft; University of Bristol; Diabetes UK; National Institute for Health and Care Research; Peking University; Academy of Medical Sciences; University Hospitals Bristol NHS Foundation Trust; British Heart Foundation; China Scholarship Council; National Institute of Diabetes and Digestive and Kidney Diseases; Peking University Health Science Center; Norges Teknisk-Naturvitenskapelige Universitet; University of Michigan","keywords":"Mendelian randomization; Kidney disease; Medicine; Ethnic group; Disease; Causality (physics); Causal inference; Internal medicine; Genetics; Biology; Genetic variants; Gene; Pathology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02058049,0.0008511904,0.0007822542,0.001009435,0.000729317,0.0006732825,0.0007953657,0.0007091158,0.002037099],"category_scores_gemma":[0.02911784,0.0003492751,0.00157334,0.001218092,0.0008936351,0.0004404406,0.0006012746,0.0005376186,0.0002132231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002981514,"about_ca_system_score_gemma":0.0005903161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001581592,"about_ca_topic_score_gemma":0.001290779,"domain_scores_codex":[0.9733657,0.02085938,0.001410877,0.002771519,0.001184909,0.000407581],"domain_scores_gemma":[0.9716077,0.01371369,0.005592895,0.007665541,0.0009639725,0.0004561511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01044041,0.0002872689,0.9538505,0.0002528675,0.009969295,0.001660895,0.000721044,0.0005816813,0.004967689,0.002311775,0.0005132906,0.0144432],"study_design_scores_gemma":[0.003874265,0.006749631,0.9319015,0.0001167368,0.01788124,0.01017297,0.0006373365,0.01289892,0.004746454,0.006581585,0.004336948,0.0001025558],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851078,0.0009370256,0.01254503,0.0001497505,0.00004923216,0.0001572886,0.0002906569,0.00007665254,0.0006866559],"genre_scores_gemma":[0.996854,0.00009612576,0.002589309,0.00008230482,0.00001711599,0.00007426104,0.0001657189,0.00001275729,0.0001083619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02058049,"threshold_uncertainty_score":0.1088413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0679534491980617,"score_gpt":0.3595689741330856,"score_spread":0.291615524935024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}