{"id":"W3083598399","doi":"10.1186/s13071-020-04321-w","title":"Bacillus sphaericus exposure reduced vector competence of Anopheles dirus to Plasmodium yoelii by upregulating the Imd signaling pathway","year":2020,"lang":"en","type":"article","venue":"Parasites & Vectors","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Chongqing; University of Toronto; National Natural Science Foundation of China","keywords":"Plasmodium yoelii; Biology; Immune system; Anopheles gambiae; RNA interference; Vector (molecular biology); Malaria; Anopheles; Larva; Microbiology; Gene; Plasmodium falciparum; Immunology; Parasitemia; Botany; RNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000790933,0.0002758826,0.0002242384,0.0001278767,0.00007799864,0.000124043,0.00008577199,0.0001204889,0.001455319],"category_scores_gemma":[0.00006191656,0.00006034569,0.0001387511,0.00006236776,0.0001494188,0.0001005595,0.0001101055,0.0003796919,0.0001482444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267727,"about_ca_system_score_gemma":0.0001598859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006048241,"about_ca_topic_score_gemma":0.0008048203,"domain_scores_codex":[0.9999359,0.00001037603,0.000005126268,0.00001112888,0.00001691906,0.00002055706],"domain_scores_gemma":[0.9999607,0.000004863442,0.000012317,0.000002681799,0.000005959263,0.00001356975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004277658,0.00008805744,0.0003680866,0.000100477,0.000005325672,0.00003465586,0.00002046634,0.00004954975,0.9964439,0.0000411284,0.0001289592,0.00229154],"study_design_scores_gemma":[0.00006689659,0.002757596,0.02382993,0.00002310979,0.00004071026,0.0001457372,0.0001043535,0.001146573,0.9680042,0.00005662419,0.003815539,0.000008658082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956874,0.001530162,0.0007589775,0.000146595,0.00003924973,0.00002690852,0.0003366916,0.00007370324,0.00140026],"genre_scores_gemma":[0.9957071,0.0008523249,0.0007266323,0.00006531413,0.00001165028,0.00003783717,0.0002901064,0.000007098837,0.002301987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455319,"threshold_uncertainty_score":0.004868507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455345350543027,"score_gpt":0.2187113636450118,"score_spread":0.2041579101395815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}