{"id":"W3083602298","doi":"10.1002/glia.23896","title":"Intranasal anti‐caspase‐1 therapy preserves myelin and glucose metabolism in a model of progressive multiple sclerosis","year":2020,"lang":"en","type":"article","venue":"Glia","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Medical Association; Women and Children’s Health Research Institute; University of Alberta","funders":"","keywords":"Microglia; Multiple sclerosis; Biology; Inflammation; Neuroprotection; Central nervous system; Myelin; Oligodendrocyte; Pathology; Cancer research; Neuroscience; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468323,0.0006341629,0.0005826012,0.0003972364,0.000222283,0.0002916969,0.0003180375,0.0004822169,0.0008338956],"category_scores_gemma":[0.00009459323,0.0001568618,0.0002663656,0.0002235785,0.0003409185,0.0003242142,0.0001360416,0.001009077,0.0002331812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003215729,"about_ca_system_score_gemma":0.0004136125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001201116,"about_ca_topic_score_gemma":0.001707325,"domain_scores_codex":[0.9998646,0.00001570455,0.00001452884,0.00003102384,0.0000319881,0.00004218526],"domain_scores_gemma":[0.9999068,0.000007023486,0.00002943173,0.00001398472,0.00001010304,0.00003265398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001085132,0.0003203353,0.00008672696,0.00006339316,0.0000113602,0.00007745397,0.00003353813,0.00008453433,0.9959707,0.0000567829,0.00004759198,0.002162301],"study_design_scores_gemma":[0.0001488631,0.006103284,0.003305263,0.00001671876,0.00004988981,0.000302204,0.00005305776,0.0007993274,0.9878693,0.00007707508,0.001266395,0.00000861332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967718,0.001207802,0.0008164863,0.00008783276,0.00003995748,0.0000388062,0.0002642775,0.000135334,0.0006378617],"genre_scores_gemma":[0.9944618,0.001188496,0.001333022,0.00004838324,0.00001182174,0.00006036122,0.0003764961,0.0000142769,0.002505333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201116,"threshold_uncertainty_score":0.002789676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03081826697583308,"score_gpt":0.2259089559482644,"score_spread":0.1950906889724314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}