{"id":"W3083626914","doi":"10.21873/anticanres.14486","title":"The Future of ER+/HER2− Metastatic Breast Cancer Therapy: Beyond PI3K Inhibitors","year":2020,"lang":"en","type":"review","venue":"Anticancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"Medicine; Breast cancer; Estrogen receptor; Cancer research; Metastatic breast cancer; Cancer; Oncology; PI3K/AKT/mTOR pathway; Targeted therapy; Internal medicine; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001333917,0.0006922792,0.002773263,0.0003615784,0.0004122696,0.00008754111,0.0009521439,0.0002665607,0.0006751724],"category_scores_gemma":[0.00008868044,0.0003936031,0.0008008525,0.002513651,0.00144757,0.0001416512,0.0003042307,0.002442535,0.00010231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000751164,"about_ca_system_score_gemma":0.004366972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003908605,"about_ca_topic_score_gemma":0.0001191559,"domain_scores_codex":[0.9938126,0.0007972266,0.001073485,0.0009217507,0.002211575,0.00118335],"domain_scores_gemma":[0.9959037,0.001011155,0.0004764111,0.001263807,0.0009343675,0.0004105759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004696898,0.0001152334,0.00003332019,0.008520665,0.001554686,0.0000772298,0.0002334753,3.448686e-7,0.00001634653,0.0006122308,0.003240852,0.9851259],"study_design_scores_gemma":[0.0009363531,0.0003009924,0.0000765501,0.00875091,0.0005091036,0.0002019635,0.0004078002,0.000003856186,0.00004803273,0.000367801,0.9880612,0.0003354555],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002203469,0.9871505,0.000008703567,0.008382258,0.0006876252,0.002692485,0.000447391,0.00006208035,0.000546902],"genre_scores_gemma":[0.0002007619,0.9937329,0.0001583457,0.0002222134,0.003321209,0.001022066,0.00004195826,0.0002476109,0.001052977],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9848203,"threshold_uncertainty_score":0.9998589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1009186523795209,"score_gpt":0.4713960969521116,"score_spread":0.3704774445725907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}