{"id":"W3083626914","doi":"10.21873/anticanres.14486","title":"The Future of ER+/HER2− Metastatic Breast Cancer Therapy: Beyond PI3K Inhibitors","year":2020,"lang":"en","type":"review","venue":"Anticancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Essar Steel Algoma (Canada); Sault Area Hospital","funders":"","keywords":"Medicine; Breast cancer; Estrogen receptor; Cancer research; Metastatic breast cancer; Cancer; Oncology; PI3K/AKT/mTOR pathway; Targeted therapy; Internal medicine; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004605058,0.0005227926,0.0008641165,0.001042064,0.00019112,0.0008115059,0.0006077489,0.0007971203,0.005089378],"category_scores_gemma":[0.0003724985,0.0001665835,0.0004601087,0.0008809591,0.0002827702,0.00124866,0.0005247766,0.002001142,0.002313101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005308735,"about_ca_system_score_gemma":0.0006883754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006282518,"about_ca_topic_score_gemma":0.001850846,"domain_scores_codex":[0.9998869,0.00002648405,0.00001144151,0.00001592842,0.00004031132,0.00001898571],"domain_scores_gemma":[0.9998472,0.00006695482,0.00001973199,0.000003960839,0.00004309106,0.0000189346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001343072,0.000105285,0.00008638988,0.009685863,0.00006382456,0.0001823419,0.00005072839,0.0004207279,0.002639018,0.005047408,0.04847126,0.9331129],"study_design_scores_gemma":[0.00003775469,0.0001458692,0.0003671577,0.001924906,0.00005425152,0.0005522355,0.00003183694,0.0001224059,0.0002896842,0.002248434,0.9942155,0.000009948702],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002271128,0.9972082,0.0001046867,0.000606944,0.0002460607,0.000004797346,0.00002146944,0.00001118732,0.001569528],"genre_scores_gemma":[0.001018678,0.9968089,0.0001777766,0.0005747888,0.0001961473,0.000007495533,0.00004195243,0.000002376205,0.001171858],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005089378,"threshold_uncertainty_score":0.01702565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1009186523795209,"score_gpt":0.4713960969521116,"score_spread":0.3704774445725907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}