{"id":"W3083685729","doi":"10.1002/chem.202003655","title":"Synthesis and Diversification of Macrocyclic Alkynediyl Sulfide Peptides","year":2020,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Cycloaddition; Tripeptide; Chemistry; Combinatorial chemistry; Halide; Sulfide; Catalysis; Peptide synthesis; Alkyne; Peptide; Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001301251,0.0003729346,0.0001974817,0.000173494,0.0001366327,0.0001916066,0.000226928,0.0001816901,0.001522328],"category_scores_gemma":[0.0001029342,0.0001237585,0.0001548506,0.0001704775,0.0001526267,0.0001827374,0.0002560162,0.0002908247,0.0006051666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000230828,"about_ca_system_score_gemma":0.0002032403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001972104,"about_ca_topic_score_gemma":0.0004254664,"domain_scores_codex":[0.9999251,0.000008198574,0.000007095694,0.00001821836,0.000019905,0.00002136644],"domain_scores_gemma":[0.999927,0.000006977044,0.00001782677,0.000009148752,0.00001175916,0.00002720291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006056844,0.00001305629,0.0001026977,0.00005360532,0.000007065325,0.0002262611,0.00003056256,0.0002646459,0.9940214,0.0004740713,0.0001140516,0.004632024],"study_design_scores_gemma":[0.00001925768,0.0003051044,0.0008579697,0.000005555157,0.000008217251,0.0003327665,0.00001240223,0.0004476834,0.9922488,0.00006957758,0.005686182,0.000006544801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755234,0.001771709,0.01279196,0.0001277146,0.0001130976,0.0001376791,0.0005530016,0.000245488,0.008735944],"genre_scores_gemma":[0.9883507,0.001118013,0.006991685,0.00004650862,0.000018511,0.00004049998,0.0002994034,0.00003144341,0.003103222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522328,"threshold_uncertainty_score":0.00509268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02527681055244506,"score_gpt":0.2195176290643875,"score_spread":0.1942408185119424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}