{"id":"W3083695050","doi":"10.1158/1538-7445.am2020-904","title":"Abstract 904: Stimulation and expansion of oncogene-reactive tumor infiltrating T cells through combined Ad-HER2Δ16 vaccination and anti-PD1 enable anti-tumor responses against established HER2 BC","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Tumor microenvironment; Immune system; Cancer research; clone (Java method); Vaccination; CD8; Tumor progression; Tumor antigen; Antigen; Tumor-infiltrating lymphocytes; Immunology; T cell; Medicine; Immunotherapy; Cancer; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001884353,0.0003563639,0.0003107636,0.0001573669,0.00008110527,0.0002260642,0.0002225818,0.0002968792,0.002495094],"category_scores_gemma":[0.0001005083,0.0001159475,0.0001991225,0.00009124864,0.0001316873,0.0001585137,0.0001520255,0.0009336972,0.0004962343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001611965,"about_ca_system_score_gemma":0.0002682462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003601385,"about_ca_topic_score_gemma":0.0004112328,"domain_scores_codex":[0.9998786,0.0000234264,0.0000111987,0.00002330806,0.00002357953,0.00003982714],"domain_scores_gemma":[0.9999367,0.00001057431,0.00001096027,0.0000092133,0.000007327153,0.0000252557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001547316,0.001121953,0.000254826,0.00005153227,0.00001220893,0.0000332573,0.00001933283,0.0002135041,0.9922807,0.00006698443,0.0002759307,0.004122504],"study_design_scores_gemma":[0.001036342,0.01900716,0.003217305,0.0000124199,0.00005074465,0.0002332876,0.00002190754,0.002055996,0.9711187,0.00007862153,0.003161641,0.000005910904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965348,0.0002906683,0.001167976,0.00007824785,0.0000441609,0.0001358376,0.0004098479,0.00009084409,0.001247431],"genre_scores_gemma":[0.9926618,0.0002135951,0.002121044,0.00008378539,0.00002288482,0.0001682261,0.0009646256,0.00002634738,0.003737715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002495094,"threshold_uncertainty_score":0.008346856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05151613807065108,"score_gpt":0.3455392777616824,"score_spread":0.2940231396910313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}