{"id":"W3083711044","doi":"10.1158/1538-7445.am2020-779","title":"Abstract 779: A phase I study of BI 754111, an anti-LAG-3 monoclonal antibody (mAb), in combination with BI 754091, an anti-PD-1 mAb: Biomarker analyses from the microsatellite stable metastatic colorectal cancer (MSS mCRC) cohort","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada); University of Alberta","funders":"","keywords":"Medicine; Immune checkpoint; Monoclonal antibody; Immune system; Biomarker; Peripheral blood mononuclear cell; CD8; Antibody; Oncology; Tumor microenvironment; Immunotherapy; T cell; Internal medicine; Cancer research; Immunology; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009647714,0.001410636,0.001185016,0.0003745413,0.0004372056,0.0009382344,0.0005857208,0.0007406457,0.002757769],"category_scores_gemma":[0.0005234638,0.0005090325,0.000780572,0.0003349747,0.00066399,0.0005089847,0.0003225678,0.002334627,0.001062523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001179945,"about_ca_system_score_gemma":0.001754928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002042853,"about_ca_topic_score_gemma":0.004431394,"domain_scores_codex":[0.999684,0.0001134953,0.0000170448,0.00006996497,0.00004508485,0.00007052487],"domain_scores_gemma":[0.9996258,0.00003456723,0.0000488363,0.0000319034,0.00002962794,0.0002292232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5704455,0.1098859,0.02660372,0.0007995081,0.002138793,0.0004300939,0.0004382857,0.003396204,0.1560509,0.0002990531,0.00928737,0.1202247],"study_design_scores_gemma":[0.2359031,0.6849892,0.05411904,0.0000461516,0.001389656,0.0006181769,0.0001313001,0.001867382,0.01482867,0.0001689441,0.005877395,0.00006101897],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950951,0.0009379168,0.0003042979,0.0002496642,0.00005815152,0.001029175,0.001119353,0.00006451438,0.001141908],"genre_scores_gemma":[0.9891606,0.0009827144,0.001438642,0.0007119598,0.00011011,0.001336227,0.003332856,0.00002567482,0.00290124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002757769,"threshold_uncertainty_score":0.009225607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1651016991836861,"score_gpt":0.4787443829453358,"score_spread":0.3136426837616497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}