{"id":"W3083715659","doi":"10.1158/1538-7445.am2020-1953","title":"Abstract 1953: Pre-clinical development of the second-generation N-terminal domain androgen receptor inhibitor, EPI-7386, for the treatment of prostate cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Androgen receptor; LNCaP; Prostate cancer; Cancer research; Cancer; Chemistry; Computational biology; Biology; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002231513,0.0005412442,0.0003464899,0.0002310244,0.0001424445,0.0004118381,0.0003128696,0.0002687472,0.006147731],"category_scores_gemma":[0.0001079682,0.000106202,0.0002233687,0.0001747348,0.0001781294,0.0001831791,0.0001466016,0.0008050561,0.001953497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004741579,"about_ca_system_score_gemma":0.0007057317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001280119,"about_ca_topic_score_gemma":0.00273338,"domain_scores_codex":[0.9999255,0.00001217855,0.000004819943,0.000009857469,0.00002588211,0.00002187086],"domain_scores_gemma":[0.9999424,0.000006059426,0.00001000419,0.000004171583,0.00001353765,0.00002372228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005124601,0.002216547,0.001402684,0.0009892327,0.000104764,0.0004308615,0.00009003807,0.001329631,0.7044978,0.001515015,0.008539174,0.2737598],"study_design_scores_gemma":[0.003012006,0.04225726,0.01989926,0.0001665934,0.0003103438,0.003327924,0.00005071643,0.003160316,0.7908785,0.000356562,0.1365307,0.00004982374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8528261,0.04988277,0.02024213,0.001268503,0.0005307453,0.001810692,0.008225556,0.001791872,0.06342164],"genre_scores_gemma":[0.9438181,0.01387268,0.006012798,0.0005191187,0.0001086911,0.0002921709,0.005294467,0.00009328229,0.02998883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006147731,"threshold_uncertainty_score":0.02056623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.185621716982253,"score_gpt":0.460539999905851,"score_spread":0.274918282923598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}