{"id":"W3083718901","doi":"10.1093/ofid/ofaa404","title":"Treatment Switch to Dolutegravir With 2 Nucleoside Reverse-Transcriptase Inhibitors (NRTI) in Comparison to Continuation With Protease Inhibitor/Ritonavir Among Patients With Human Immunodeficiency Virus at Risk for Prior NRTI Resistance: A Cohort Analysis of Real-World Data","year":2020,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; McGill University; Centre Hospitalier de l’Université de Montréal; McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Université de Montréal; Canadian Institutes of Health Research; Islamic Development Bank; ViiV Healthcare","keywords":"Dolutegravir; Virology; Medicine; Ritonavir; Nucleoside Reverse Transcriptase Inhibitor; Reverse transcriptase; Protease inhibitor (pharmacology); Reverse-transcriptase inhibitor; Protease; Virus; Antiretroviral therapy; Viral load; Biology; Enzyme; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003056532,0.0004366602,0.0004445977,0.0004741394,0.0005556674,0.0008068176,0.0008068398,0.0006104794,0.001885164],"category_scores_gemma":[0.004701096,0.0002637036,0.001520411,0.0006245411,0.0004298761,0.000464914,0.0005252894,0.001008934,0.0001213336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002101178,"about_ca_system_score_gemma":0.001568345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1388115,"about_ca_topic_score_gemma":0.1413662,"domain_scores_codex":[0.998632,0.0005212059,0.00007565869,0.0003591065,0.0001697645,0.0002422219],"domain_scores_gemma":[0.9967697,0.001088649,0.00110349,0.0003726682,0.0002342669,0.0004311746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007986872,0.0002768763,0.9870061,0.00002977615,0.001054331,0.00005448134,0.0001423869,0.0003451198,0.0003036955,0.00003049186,0.000198192,0.002571706],"study_design_scores_gemma":[0.0005173544,0.002776677,0.9922053,0.00002153067,0.0005941572,0.00009494578,0.0002347821,0.002944249,0.000174807,0.00003856695,0.0003815562,0.00001599059],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991673,0.0001648887,0.00006277357,0.00002534599,0.000005283582,0.00002762932,0.0004564404,0.000001658396,0.00008871713],"genre_scores_gemma":[0.9991974,0.00006225328,0.00008130717,0.00002639023,0.000004757556,0.00002154882,0.0004750321,0.00000152715,0.0001296575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1388115,"threshold_uncertainty_score":0.276007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0198815739485389,"score_gpt":0.3007526553480875,"score_spread":0.2808710813995486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}