{"id":"W3083718901","doi":"10.1093/ofid/ofaa404","title":"Treatment Switch to Dolutegravir With 2 Nucleoside Reverse-Transcriptase Inhibitors (NRTI) in Comparison to Continuation With Protease Inhibitor/Ritonavir Among Patients With Human Immunodeficiency Virus at Risk for Prior NRTI Resistance: A Cohort Analysis of Real-World Data","year":2020,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; McGill University; Centre Hospitalier de l’Université de Montréal; McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Université de Montréal; Canadian Institutes of Health Research; Islamic Development Bank; ViiV Healthcare","keywords":"Dolutegravir; Virology; Medicine; Ritonavir; Nucleoside Reverse Transcriptase Inhibitor; Reverse transcriptase; Protease inhibitor (pharmacology); Reverse-transcriptase inhibitor; Protease; Virus; Antiretroviral therapy; Viral load; Biology; Enzyme; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000184189,0.000548439,0.00135882,0.0005712666,0.0004206728,0.0001248251,0.0003180164,0.00005477311,0.0000356659],"category_scores_gemma":[0.0000846738,0.0003738171,0.0001432151,0.002474512,0.0001373039,0.0004455473,0.0001971451,0.0001256286,0.00000862823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009164709,"about_ca_system_score_gemma":0.0003318023,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01156007,"about_ca_topic_score_gemma":0.1592139,"domain_scores_codex":[0.9966694,0.0001177289,0.0008412006,0.001148005,0.0006867407,0.0005369637],"domain_scores_gemma":[0.9975427,0.000079158,0.000555441,0.0009386888,0.0003236359,0.0005603293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01411584,0.003374905,0.9751498,0.00008765603,0.002200269,0.00003927511,0.001415718,0.0003156009,0.0001804751,0.00001620211,0.002223637,0.00088059],"study_design_scores_gemma":[0.01229559,0.004375275,0.9712567,0.0005314952,0.006991329,5.274049e-7,0.0005235135,0.0001561382,0.001614369,0.000003969839,0.001738928,0.0005121351],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845271,0.00005688462,0.0001599865,0.0006448281,0.00002481323,0.01180502,0.002190878,0.00008183721,0.0005086918],"genre_scores_gemma":[0.9921997,0.00001486931,0.001220865,0.000148517,0.00002038145,0.002009451,0.00369617,0.00007663662,0.0006134619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1476538,"threshold_uncertainty_score":0.9998714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0198815739485389,"score_gpt":0.3007526553480875,"score_spread":0.2808710813995486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}