{"id":"W3083765282","doi":"10.1002/acn3.51164","title":"Longitudinal Measurements of Glucocerebrosidase activity in Parkinson’s patients","year":2020,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; NIH Clinical Center; National Institutes of Health; Michael J. Fox Foundation for Parkinson's Research","keywords":"Glucocerebrosidase; Medicine; Parkinson's disease; Sanger sequencing; Internal medicine; Cohort; Genotyping; Exome sequencing; Genotype; Gastroenterology; Oncology; Disease; Phenotype; Genetics; Gene; DNA sequencing; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003213808,0.00007697784,0.000424673,0.00005217056,0.00001265154,0.000001435707,0.0000575715,0.0001073551,0.00006775467],"category_scores_gemma":[0.0005586782,0.00006750641,0.0001139392,0.0001427996,0.0002322142,0.00005636257,0.00002095492,0.0002564595,0.000002520978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":1.882518e-7,"about_ca_system_score_gemma":0.0000673381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004892439,"about_ca_topic_score_gemma":0.00003429123,"domain_scores_codex":[0.9985658,0.0001744993,0.0005284004,0.0002436407,0.000348341,0.0001393208],"domain_scores_gemma":[0.9991543,0.0003177909,0.0001085245,0.0000704074,0.0002012715,0.0001477255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00593658,0.0008046865,0.9795596,0.00009631196,0.00004481391,0.00000882415,0.00004151754,0.000009403757,0.0002137199,0.00003668492,0.00005090557,0.01319694],"study_design_scores_gemma":[0.003416251,0.001423297,0.9933034,0.00001052784,0.0000132698,0.000001009549,6.671605e-7,0.0003148324,0.0009394333,0.0002442539,0.0002914423,0.00004160061],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810331,0.000101545,0.0000259449,0.01820724,0.00002693937,0.0001937719,0.00001899649,0.000004280653,0.0003881486],"genre_scores_gemma":[0.9981977,0.00009296102,0.00005335777,0.001600536,0.00003420011,0.000003032287,0.00001004604,0.000006066346,0.000002086175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01716458,"threshold_uncertainty_score":0.2752832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2987740821870022,"score_gpt":0.4334431308353539,"score_spread":0.1346690486483516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}