{"id":"W3083789386","doi":"10.1080/02656736.2020.1812737","title":"The effect of injected dose on localized tumor accumulation and cardiac uptake of doxorubicin in a Vx2 rabbit tumor model using MR-HIFU mild hyperthermia and thermosensitive liposomes","year":2020,"lang":"en","type":"article","venue":"International Journal of Hyperthermia","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Profound Medical (Canada)","funders":"National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas","keywords":"Hyperthermia; Doxorubicin; Medicine; Liposome; Drug delivery; Pharmacology; Chemotherapy; Distribution (mathematics); Chemistry; Nuclear medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007523362,0.0002016366,0.0005191706,0.0001562121,0.00005299773,0.00005731649,0.0002800518,0.00004863369,0.00001293139],"category_scores_gemma":[0.0004983792,0.0001335194,0.0001201436,0.000162232,0.0002015561,0.0002647507,0.00009060631,0.000187988,0.000002193821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000083945,"about_ca_system_score_gemma":0.0001325434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001222595,"about_ca_topic_score_gemma":0.00001415995,"domain_scores_codex":[0.9978713,0.0003369204,0.000772321,0.0002142041,0.0006204844,0.0001848057],"domain_scores_gemma":[0.9980145,0.0007687207,0.0006354501,0.0001316945,0.0003512577,0.00009835601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004561851,0.00004638487,0.004863463,0.00002279095,0.00008598544,0.00006227772,0.000847668,0.02573708,0.9607922,0.00003545166,0.000008800019,0.002936071],"study_design_scores_gemma":[0.00322151,0.0006300102,0.008569193,0.0003032978,0.00007820847,0.00006881885,0.0002045701,0.1153193,0.8713161,0.0001343189,0.00001305197,0.0001415342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982726,0.0006883109,0.0000435263,0.0004529836,0.0002140951,0.0002598625,0.00003941363,0.000009401202,0.00001978123],"genre_scores_gemma":[0.9992864,0.00004579372,0.0003165675,0.0002130642,0.0001054447,0.000002932001,0.000001176813,0.00002497746,0.000003677266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08958225,"threshold_uncertainty_score":0.5444763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02554495386736926,"score_gpt":0.2827587433156474,"score_spread":0.2572137894482781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}