{"id":"W3083798800","doi":"10.1038/s41523-020-00185-6","title":"Association of germline variation with the survival of women with BRCA1/2 pathogenic variants and breast cancer","year":2020,"lang":"en","type":"article","venue":"npj Breast Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McGill University; Centre hospitalier universitaire de Québec","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Medical Research Council; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Odense Universitetshospital; Fondation du cancer du sein du Québec; Génome Québec; Genome Canada; National Institutes of Health; National Health and Medical Research Council; Cancer Research UK; Government of Canada; Deutsche Krebshilfe; Breast Cancer Research Foundation","keywords":"Germline; Breast cancer; Germline mutation; Oncology; Genetics; Variation (astronomy); Biology; Medicine; Internal medicine; Cancer; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004214697,0.0001412045,0.0001450672,0.0003530125,0.0001844058,0.0002481958,0.0001564731,0.0002176405,0.001996116],"category_scores_gemma":[0.001552844,0.00006905727,0.0002277767,0.0003586221,0.0001815197,0.00009603188,0.0001925667,0.0002816654,0.0001153725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008939613,"about_ca_system_score_gemma":0.0001098757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154905,"about_ca_topic_score_gemma":0.001059648,"domain_scores_codex":[0.9998049,0.00006137336,0.00001647057,0.00005446211,0.00002877812,0.00003404988],"domain_scores_gemma":[0.9992338,0.0003036908,0.0002562602,0.00006448166,0.00005339125,0.0000884439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003646973,0.00002410625,0.994689,0.000006353207,0.0001151275,0.0001473277,0.00002486077,0.0001336221,0.002337785,0.00005003432,0.0000817516,0.002025373],"study_design_scores_gemma":[0.000007912431,0.0001118376,0.9980828,0.000002510211,0.00005874283,0.0005026602,0.00003656215,0.0004588916,0.0005076218,0.000086796,0.0001409591,0.000002671876],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993308,0.0001670346,0.0001352734,0.00002757445,0.000004766543,9.835596e-7,0.0001285795,0.000003488794,0.0002016056],"genre_scores_gemma":[0.9997723,0.00002580756,0.0000424592,0.000006310545,0.000003929586,7.295281e-7,0.00007442036,8.972031e-7,0.00007316442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001996116,"threshold_uncertainty_score":0.006677747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005966913367636,"score_gpt":0.2273153082776421,"score_spread":0.2213483949100061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}