{"id":"W3083872981","doi":"10.1007/112_2020_48","title":"Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk","year":2020,"lang":"en","type":"review","venue":"Reviews of physiology, biochemistry and pharmacology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Ion channel; Crosstalk; Neuroscience; Stromal cell; Carcinogenesis; Cancer; Transmembrane protein; Tumor microenvironment; Cancer cell; Cell biology; Chemistry; Biology; Cancer research; Medicine; Tumor cells; Biochemistry; Internal medicine; Engineering; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002791921,0.0003694959,0.001611576,0.00007349777,0.0000349052,0.000004245403,0.0001608689,0.0006296223,0.00006324406],"category_scores_gemma":[0.00007827795,0.0003209931,0.0002597297,0.0002419397,0.0002994659,0.000004091674,0.000126719,0.000298616,8.872148e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002186636,"about_ca_system_score_gemma":0.0001842963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007421776,"about_ca_topic_score_gemma":2.417493e-7,"domain_scores_codex":[0.9979875,0.0003082937,0.0008240782,0.0005860795,0.00006013662,0.0002339034],"domain_scores_gemma":[0.9989666,0.00006936244,0.0006469712,0.00015006,0.0000571074,0.000109925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006444988,0.00006585488,0.000005944713,0.01530276,0.000103916,0.000001426503,0.00001663069,0.000006528521,0.884844,0.000005978919,0.0003655526,0.09921694],"study_design_scores_gemma":[0.0003031079,0.0001753508,0.000001405658,0.000678129,0.0002096729,0.00001028128,0.000006174281,0.00003246588,0.4577683,0.00001136399,0.5405941,0.0002096255],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.030362,0.9686596,0.00001172817,0.00002554362,0.0003369598,0.0005233221,0.0000584381,0.000004442978,0.00001795204],"genre_scores_gemma":[0.02265811,0.9758903,0.00003339468,0.00004873903,0.0008740521,0.0001094225,0.0003254839,0.00002257774,0.00003796934],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5402286,"threshold_uncertainty_score":0.9999242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.041295577614613,"score_gpt":0.352685021297438,"score_spread":0.311389443682825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}