{"id":"W3083892901","doi":"10.1016/j.cyto.2020.155267","title":"Cytokines and metabolic regulation: A framework of bidirectional influences affecting Leishmania infection","year":2020,"lang":"en","type":"review","venue":"Cytokine","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"European Regional Development Fund; Fondation pour la Recherche Médicale; Bundesministerium für Bildung und Forschung; Agence Nationale de la Recherche; Canada Research Chairs; European Society of Clinical Microbiology and Infectious Diseases; Fundação para a Ciência e a Tecnologia; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Leishmania; Immune system; Biology; Phenotype; Amastigote; Cell biology; Host (biology); Macrophage; Leishmania major; Metabolic pathway; Immunology; Metabolism; Parasite hosting; In vitro; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005844683,0.0008638897,0.001217493,0.002177198,0.0002184938,0.001642349,0.0006425158,0.001031321,0.002138725],"category_scores_gemma":[0.0007462967,0.0002104083,0.0003332245,0.002682706,0.0005378958,0.001334806,0.0007369476,0.00146422,0.0006953706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000562605,"about_ca_system_score_gemma":0.001192034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008764213,"about_ca_topic_score_gemma":0.001676883,"domain_scores_codex":[0.999818,0.00004996189,0.00003186887,0.00003377935,0.00004583025,0.00002052046],"domain_scores_gemma":[0.9996843,0.0001831602,0.00004733978,0.000005797351,0.00005800966,0.00002134785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002388279,0.00007962886,0.0004727578,0.03050365,0.0001591671,0.0003050193,0.0001480668,0.0003688426,0.002370816,0.009634869,0.01738399,0.9383345],"study_design_scores_gemma":[0.00005332588,0.0001692934,0.002046943,0.01326192,0.0003887505,0.001735202,0.0002546421,0.0002211283,0.0006803852,0.006170008,0.9749835,0.0000348316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006886655,0.9992791,0.00006949822,0.0001640707,0.000105627,0.000001919225,0.000009126672,0.000002345558,0.0002994844],"genre_scores_gemma":[0.0006821484,0.9986299,0.0001554003,0.0001362545,0.0002283858,0.000003930002,0.00001214726,5.430651e-7,0.0001513249],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002177198,"threshold_uncertainty_score":0.007154763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0590697294774837,"score_gpt":0.368451200709376,"score_spread":0.3093814712318923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}