{"id":"W3083906113","doi":"10.1007/s00401-020-02209-8","title":"Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patterns","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba; Princess Margaret Cancer Centre; Izaak Walton Killam Health Centre; University of Manitoba; SickKids Foundation; Université Laval; Hospital for Sick Children","funders":"Stand Up To Cancer; Brain Tumour Charity; Cancer Research UK; Royal Children's Hospital Foundation","keywords":"Germline; Replication (statistics); Biology; Genetics; Computational biology; Virology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715822,0.0002627915,0.000374285,0.0001265396,0.0001169892,0.00002475693,0.0001403199,0.0001291761,0.000110072],"category_scores_gemma":[0.0006105181,0.0002045497,0.0002100504,0.0004902101,0.00004980293,0.00008773697,0.0001225297,0.0002399544,0.0001171052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000650634,"about_ca_system_score_gemma":0.00002866003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002308182,"about_ca_topic_score_gemma":0.000001932591,"domain_scores_codex":[0.9978154,0.0002051837,0.0004406702,0.0009051575,0.000329405,0.0003042193],"domain_scores_gemma":[0.9983888,0.000127889,0.0002231314,0.0008864471,0.0001132729,0.0002604497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001788393,0.001275696,0.3209698,0.00008204518,0.0000480786,0.003670859,0.0003759566,0.0001055898,0.6678898,0.0006436229,0.001925002,0.002834813],"study_design_scores_gemma":[0.001555618,0.001970485,0.9292688,0.00004543165,0.000206731,0.0003637983,0.00003549359,0.001261207,0.05722319,0.00005591619,0.007749252,0.00026406],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805993,0.0001355286,0.0002162744,0.01715695,0.0000998695,0.0007638325,0.00003975837,0.0006231721,0.000365328],"genre_scores_gemma":[0.9937686,0.0002587344,0.001635935,0.003775072,0.0001785637,0.0001242111,0.0001899628,0.00004228283,0.00002658894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6106666,"threshold_uncertainty_score":0.8341295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04481276834197525,"score_gpt":0.278727090589014,"score_spread":0.2339143222470388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}