{"id":"W3083972440","doi":"10.1101/2020.09.07.286567","title":"Interaction of human ACE2 to membrane-bound SARS-CoV-1 and SARS-CoV-2 S glycoproteins","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"U.S. Military HIV Research Program; Canadian Institutes of Health Research; Uniformed Services University of the Health Sciences; Mitacs; Fondation du CHUM; U.S. Department of Defense","keywords":"Glycoprotein; Spike (software development); Coronavirus; Cooperativity; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Plasma protein binding; Receptor; Cooperative binding; Chemistry; Viral entry; Biophysics; Coronavirus disease 2019 (COVID-19); Binding site; Biology; Virology; Virus; Biochemistry; Medicine; Disease; Computer science; Viral replication","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001630186,0.0001954653,0.0001669355,0.0000921456,0.0001520168,0.0001961432,0.0001817738,0.0001539942,0.002194174],"category_scores_gemma":[0.0002521011,0.00007428591,0.0001859874,0.00009492404,0.0001158641,0.0001109579,0.0001032506,0.000254701,0.0003328904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002761803,"about_ca_system_score_gemma":0.0001217776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121923,"about_ca_topic_score_gemma":0.0009962341,"domain_scores_codex":[0.9998772,0.0000284436,0.000005282815,0.00002557495,0.00003165671,0.00003181139],"domain_scores_gemma":[0.9999284,0.00002449992,0.0000111409,0.000007500018,0.00001019194,0.00001831765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005470025,0.000116676,0.002479235,0.00004289495,0.00003222696,0.00009643139,0.00004005596,0.000620244,0.9938874,0.0002754291,0.0003890112,0.001473395],"study_design_scores_gemma":[0.00005547335,0.0004274801,0.02088496,0.000007019724,0.00002108008,0.0003186078,0.00007957489,0.01773014,0.9576348,0.000134301,0.002694883,0.00001165531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981349,0.0003756662,0.0006078166,0.00005189254,0.00001874022,0.000005497332,0.0001166013,0.00001192578,0.0006770549],"genre_scores_gemma":[0.9972118,0.0001711811,0.000790065,0.00005251534,0.00001094134,0.000005861149,0.0005097841,0.000008021761,0.001239864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002194174,"threshold_uncertainty_score":0.007340193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05732261693947894,"score_gpt":0.3344672143695486,"score_spread":0.2771445974300696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}