{"id":"W3083973029","doi":"10.1111/jcpt.13255","title":"Extremely low dose of 6‐mercaptopurine in a Chinese child with acute lymphoblastic leukaemia and multiple pharmacogenetic mutations","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Pharmacy and Therapeutics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Health Commission of Hebei Province; National Major Science and Technology Projects of China; Department of Education of Shandong Province; Shandong University","keywords":"Mercaptopurine; Medicine; Pharmacogenetics; Incidence (geometry); Adverse effect; Pediatrics; Thiopurine methyltransferase; Pharmacology; Internal medicine; Genotype; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002275021,0.00077509,0.000577959,0.0009674408,0.001577979,0.0004424394,0.0005848656,0.00135598,0.001438345],"category_scores_gemma":[0.0009271535,0.0003560056,0.0004186937,0.001049213,0.0009895415,0.0007562476,0.0006276018,0.001519879,0.0001621914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00136368,"about_ca_system_score_gemma":0.001225692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0147856,"about_ca_topic_score_gemma":0.01388077,"domain_scores_codex":[0.9997359,0.00003977034,0.00003007069,0.00006676788,0.00004280804,0.00008476332],"domain_scores_gemma":[0.9994611,0.0001378282,0.0001613573,0.0000209448,0.00003088591,0.0001879072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00006561652,0.00004500245,0.05449457,0.00004817365,0.00001363446,0.9407358,0.0006064816,0.0001090077,0.001144811,0.0002561705,0.0003789442,0.002101761],"study_design_scores_gemma":[0.00001449188,0.0001439018,0.06228514,0.00004842499,0.00004792005,0.9345091,0.000807458,0.0003288441,0.0005531051,0.0002162912,0.001026479,0.00001884413],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993502,0.001328565,0.0003651462,0.002131793,0.00004410504,0.00004922634,0.0001265187,0.00002640055,0.002426367],"genre_scores_gemma":[0.9978036,0.0007824104,0.0003944935,0.0004652677,0.00006354836,0.000007263,0.00005716454,0.000008400595,0.0004178478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0147856,"threshold_uncertainty_score":0.02939904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06470461062237993,"score_gpt":0.404670949832012,"score_spread":0.339966339209632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}