{"id":"W3084026776","doi":"10.1242/dev.180042","title":"IRX3/5 regulate mitotic chromatid segregation and limb bud shape","year":2020,"lang":"en","type":"article","venue":"Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Toronto Centre for Phenogenomics; SickKids Foundation; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Sinai Health System; Hospital for Sick Children","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Biology; Limb bud; Primordium; Morphogenesis; Cell biology; Mitosis; Chromatid; Cell cycle; Cohesin; Cell division; Cell; DNA; Genetics; Chromosome; Gene; Embryo; Chromatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005689344,0.000115814,0.00009383912,0.00001368985,0.00007194587,0.00003020901,0.0000910085,0.00007357629,0.00001914319],"category_scores_gemma":[0.00001590711,0.0001154783,0.00002257901,0.00004419132,0.00002402133,0.000002223142,0.0001248318,0.00003869331,0.00002333372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001450481,"about_ca_system_score_gemma":0.00007170011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001074611,"about_ca_topic_score_gemma":0.000005612021,"domain_scores_codex":[0.9993445,0.00001294016,0.0001724826,0.0002476393,0.00008174919,0.0001407119],"domain_scores_gemma":[0.9997053,0.000003257416,0.00005601805,0.0001083401,0.00003034823,0.0000967667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000657552,0.00005564423,0.003824948,0.0001711717,0.0001628198,0.000009730447,0.001441538,0.0002478137,0.9401978,0.0003917013,0.002701137,0.05072997],"study_design_scores_gemma":[0.002321656,0.0006995997,0.2674283,0.00007770118,0.00005347758,0.0000727377,0.0004040102,0.03385526,0.5094363,0.0003457663,0.1839125,0.00139271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979457,0.0002474762,0.0005063321,0.0006489035,0.00005455403,0.0001159026,0.000003340212,0.00001491423,0.0004629038],"genre_scores_gemma":[0.9902943,0.00008292466,0.008540281,0.0006211462,0.00006952771,0.000009895828,0.0001459474,0.00001734004,0.0002186854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4307615,"threshold_uncertainty_score":0.4709069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008917848784214288,"score_gpt":0.1940832720929778,"score_spread":0.1851654233087636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}