{"id":"W3084026776","doi":"10.1242/dev.180042","title":"IRX3/5 regulate mitotic chromatid segregation and limb bud shape","year":2020,"lang":"en","type":"article","venue":"Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Toronto Centre for Phenogenomics; SickKids Foundation; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Sinai Health System; Hospital for Sick Children","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Biology; Limb bud; Primordium; Morphogenesis; Cell biology; Mitosis; Chromatid; Cell cycle; Cohesin; Cell division; Cell; DNA; Genetics; Chromosome; Gene; Embryo; Chromatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000867611,0.0002336853,0.0001053319,0.0001642769,0.0001625776,0.0002989441,0.0001611685,0.0001921877,0.001355243],"category_scores_gemma":[0.00006090956,0.0001162081,0.0001538112,0.00007409496,0.0001712703,0.0001266624,0.0002663318,0.0002307205,0.0003744685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002812307,"about_ca_system_score_gemma":0.0001321218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00062729,"about_ca_topic_score_gemma":0.001687126,"domain_scores_codex":[0.9999328,0.00001038273,0.000003607188,0.00001574136,0.00001797829,0.00001951674],"domain_scores_gemma":[0.9999504,0.000004522592,0.00001843874,0.000004043785,0.000004632537,0.00001793718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007453688,0.000007335041,0.001092511,0.00001236054,0.000003103675,0.00003828423,0.000009851596,0.00006339543,0.9972637,0.0001498807,0.00002780399,0.001257183],"study_design_scores_gemma":[0.00001643522,0.0001120599,0.1332203,0.00001053426,0.00002073156,0.0002906547,0.00008718902,0.002275267,0.8608981,0.0001735693,0.002889384,0.000005805104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993804,0.001189442,0.002191022,0.00003697304,0.000008133572,0.000007156267,0.0001411264,0.00005987562,0.002562245],"genre_scores_gemma":[0.9952552,0.0002799876,0.001010297,0.00003183138,0.00000291763,0.00000660588,0.0001879518,0.00002163482,0.003203526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001355243,"threshold_uncertainty_score":0.004533708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008917848784214288,"score_gpt":0.1940832720929778,"score_spread":0.1851654233087636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}