{"id":"W3084137844","doi":"10.1101/2020.09.09.289280","title":"Myogenic Vasoconstriction Requires Canonical G <sub>q/11</sub> Signaling of the Angiotensin II Type 1a Receptor in the Murine Vasculature","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Vasoconstriction; Myogenic contraction; Angiotensin II; Mesenteric arteries; Internal medicine; Endocrinology; Cerebral arteries; Receptor; Signal transduction; Gq alpha subunit; Chemistry; Cell biology; Biology; G protein; Medicine; Artery; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002092275,0.0003639615,0.0002375673,0.0005568282,0.0001871279,0.0002873745,0.000255212,0.0003558394,0.001647509],"category_scores_gemma":[0.0001142767,0.0002984802,0.0003859893,0.0001517426,0.0003472429,0.0002670145,0.000189112,0.0008524046,0.0007627343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003749686,"about_ca_system_score_gemma":0.000199835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006367207,"about_ca_topic_score_gemma":0.001010319,"domain_scores_codex":[0.9997726,0.00003760053,0.00002397361,0.00005983216,0.00004835238,0.00005761521],"domain_scores_gemma":[0.9997547,0.00001967406,0.00009802118,0.00002359824,0.00001636031,0.00008775851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000140539,0.00002393442,0.0001484953,0.00001721464,0.000002620981,0.0000409841,0.000008737326,0.00005506431,0.9990097,0.0001225163,0.00003879131,0.0003913224],"study_design_scores_gemma":[0.00009162592,0.001118241,0.01159275,0.00002208471,0.00004040645,0.0005132339,0.00006476013,0.001756425,0.9818766,0.0001291079,0.002785119,0.000009589113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933159,0.0009709086,0.002977464,0.0001717963,0.00003958654,0.00004292748,0.0008058509,0.0001278716,0.001547825],"genre_scores_gemma":[0.9892497,0.001011663,0.003394485,0.000122421,0.0000234314,0.0001167284,0.0007788088,0.00007170971,0.005230867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001647509,"threshold_uncertainty_score":0.005511463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204443542454241,"score_gpt":0.208091007328678,"score_spread":0.1960465719041356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}