{"id":"W3084151935","doi":"10.1101/2020.09.10.286948","title":"Real-time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Mitacs; Canadian Institutes of Health Research; National Institutes of Health; Vaccine Research Center; Fondation du CHUM","keywords":"Allosteric regulation; Immunogen; Conformational change; Biophysics; Dynamics (music); Förster resonance energy transfer; Virus; Chemistry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Biology; Virology; Physics; Antibody; Biochemistry; Monoclonal antibody; Receptor; Medicine; Fluorescence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743072,0.0002072435,0.000203211,0.0001858678,0.0002101658,0.0003437774,0.0002622401,0.0003347097,0.001522042],"category_scores_gemma":[0.0002113112,0.0001489521,0.0001717462,0.0001373865,0.0002279835,0.0003639599,0.0001915655,0.0005126193,0.0002755435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004395393,"about_ca_system_score_gemma":0.000149406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006886353,"about_ca_topic_score_gemma":0.0007770542,"domain_scores_codex":[0.999925,0.000006487226,0.000001835892,0.00002451407,0.00002281997,0.00001943326],"domain_scores_gemma":[0.9999207,0.0000264361,0.00001451204,0.000008445858,0.00001345623,0.00001643245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000175618,0.00005622259,0.001750486,0.000042237,0.00001567125,0.0001207872,0.0001541235,0.001802386,0.9910833,0.0003876585,0.0003787121,0.004032928],"study_design_scores_gemma":[0.00007154065,0.000515676,0.03652454,0.00001465857,0.00002595928,0.0002972701,0.0003252663,0.1232496,0.8353285,0.0005846692,0.003001563,0.00006086097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962025,0.0001254198,0.002161147,0.00008963209,0.0000142472,0.00001069496,0.0002097559,0.0001124365,0.001074134],"genre_scores_gemma":[0.9955285,0.00018947,0.002982944,0.00004987851,0.00001332595,0.00002549613,0.0002971673,0.00002708268,0.0008861369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522042,"threshold_uncertainty_score":0.005091727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04226881741131065,"score_gpt":0.3046176326369255,"score_spread":0.2623488152256149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}