{"id":"W3084182198","doi":"10.1101/2020.09.08.288241","title":"Genome-wide Chromatin Accessibility is Restricted by ANP32E","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Center, University of Rochester; Huntsman Cancer Institute; Institute of Genetics; University of Rochester","keywords":"Chromatin; ChIA-PET; Nucleosome; Biology; Genetics; ChIP-sequencing; Epigenetics; Genome; Scaffold/matrix attachment region; Epigenomics; Histone; Promoter; Gene; Computational biology; Cell biology; Chromatin remodeling; Gene expression; DNA methylation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920698,0.0002371699,0.0001697984,0.0002045477,0.0001628842,0.0003500337,0.0001394616,0.0001673282,0.001174163],"category_scores_gemma":[0.000147455,0.0001748957,0.0001382167,0.000121245,0.0002756087,0.0001252333,0.0003245426,0.0002973543,0.0003035398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001981339,"about_ca_system_score_gemma":0.0001109948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006611714,"about_ca_topic_score_gemma":0.0009242728,"domain_scores_codex":[0.9998803,0.00001987353,0.000007436046,0.00004061091,0.00003380678,0.00001790404],"domain_scores_gemma":[0.9998649,0.00003750873,0.00003233421,0.00002532378,0.00001091281,0.00002894566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003805354,0.000002687729,0.0002951542,0.000005310172,0.000002123462,0.00001671113,0.000003146502,0.00003081217,0.999246,0.00005294564,0.00001088148,0.0002961964],"study_design_scores_gemma":[0.00001361228,0.00005495017,0.01001776,0.000002567092,0.000007377994,0.0001648182,0.00001403228,0.0007627651,0.9873137,0.0001608533,0.001483095,0.000004468387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912593,0.0008109285,0.005731699,0.00007646587,0.00001587593,0.00001105031,0.0003314732,0.00007852026,0.001684662],"genre_scores_gemma":[0.9965905,0.0002838188,0.001496952,0.00002526939,0.000004354534,0.00001298905,0.0002414774,0.00002468325,0.001319859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001174163,"threshold_uncertainty_score":0.003927946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009677824774517495,"score_gpt":0.2172179851726968,"score_spread":0.2075401603981793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}