{"id":"W3084251260","doi":"10.1021/acscatal.0c02760","title":"Challenging Metathesis Catalysts with Nucleophiles and Brønsted Base: Examining the Stability of State-of-the-Art Ruthenium Carbene Catalysts to Attack by Amines","year":2020,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Norges Forskningsråd","keywords":"Carbene; Morpholine; Chemistry; Nucleophile; Ruthenium; Medicinal chemistry; Catalysis; Metathesis; Salt metathesis reaction; Organic chemistry; Polymerization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005489404,0.0004146764,0.0008401676,0.00004378804,0.0001500556,0.00003500022,0.0008550236,0.0001064491,0.00008275727],"category_scores_gemma":[0.001106813,0.0002762641,0.0001595841,0.0008986777,0.000398854,0.0001068521,0.0004938181,0.0002402548,0.0000047531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006594966,"about_ca_system_score_gemma":0.00007121677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002310565,"about_ca_topic_score_gemma":0.00008843857,"domain_scores_codex":[0.9973878,0.0001203391,0.0007126094,0.000767435,0.0006298295,0.0003820071],"domain_scores_gemma":[0.9965947,0.00096462,0.0004741855,0.00155099,0.0001843451,0.000231215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007053204,0.00007479108,0.00403576,0.0005115357,0.0006087493,0.000002685159,0.006426756,0.00004613406,0.9844956,0.000001178078,0.0002372247,0.003489102],"study_design_scores_gemma":[0.0003367335,0.00002749499,0.0006364013,0.000090482,0.0007985266,0.00001358129,0.002989484,0.0001571786,0.9942901,0.000004979763,0.000350825,0.0003042634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964352,0.0007129067,0.00013997,0.0015405,0.00002262821,0.0001797339,0.0003087194,0.00005943541,0.00060087],"genre_scores_gemma":[0.9986848,0.00003000664,0.0008637037,0.00006485503,0.00004537716,0.00003358532,0.00008202594,0.00007316013,0.0001224816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009794498,"threshold_uncertainty_score":0.9999689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03286953082886303,"score_gpt":0.2390967955902731,"score_spread":0.2062272647614101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}