{"id":"W3084259645","doi":"10.1101/2020.09.08.287482","title":"Antibody binding to SARS-CoV-2 S glycoprotein correlates with, but does not predict neutralization","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Héma-Québec; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; U.S. Military HIV Research Program; Mitacs; Fondation du CHUM","keywords":"Neutralization; Glycoprotein; Monoclonal antibody; Antibody; Virology; Context (archaeology); Chemistry; Recombinant DNA; Neutralizing antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Molecular biology; Coronavirus disease 2019 (COVID-19); Biology; Biochemistry; Immunology; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005119863,0.0004357884,0.0003536658,0.0006741401,0.000116471,0.0005061603,0.000166526,0.0004981212,0.002061966],"category_scores_gemma":[0.001031531,0.0002359807,0.0002500103,0.0002586936,0.000320239,0.0002207524,0.000226353,0.0005836099,0.000757464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002463146,"about_ca_system_score_gemma":0.0002414592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001018862,"about_ca_topic_score_gemma":0.0006341481,"domain_scores_codex":[0.9994404,0.0001156352,0.00004276263,0.0001096444,0.0001739937,0.0001175868],"domain_scores_gemma":[0.999386,0.0002368211,0.0001278745,0.00006576033,0.00009467139,0.0000888467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005609599,0.0001807285,0.02864296,0.0000893265,0.0000471106,0.0001655888,0.00007212244,0.0002650137,0.9634368,0.0001352046,0.0003676121,0.006036567],"study_design_scores_gemma":[0.00005293822,0.001683945,0.41752,0.00003080112,0.00008441942,0.003142601,0.0001280743,0.005887039,0.5682,0.0003369118,0.002911387,0.00002188927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912629,0.001723865,0.002982471,0.0001050153,0.00004594211,0.00006914067,0.0003990138,0.0000761679,0.003335346],"genre_scores_gemma":[0.9960342,0.0003036335,0.001116805,0.00009475533,0.00003073915,0.00002740078,0.000720994,0.00001030112,0.001661166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002061966,"threshold_uncertainty_score":0.006897926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03057724971868288,"score_gpt":0.2977353663951117,"score_spread":0.2671581166764289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}