{"id":"W3084261375","doi":"10.1080/23723556.2020.1805095","title":"p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis","year":2020,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Cancer Council NSW; National Health and Medical Research Council; Petre Foundation; Victorian Cancer Agency","keywords":"Cilium; Ciliogenesis; Hedgehog; Hedgehog signaling pathway; Cell biology; Autophagy; Biology; Corepressor; Transcription factor; Transcription (linguistics); Cancer research; Gene; Signal transduction; Repressor; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004000129,0.0004341523,0.000584132,0.0001083028,0.0001884883,0.00003547838,0.0003633351,0.0005187845,0.00004225697],"category_scores_gemma":[0.0004992631,0.0004598468,0.0001986281,0.0003446684,0.0003614157,0.000005831891,0.0005129088,0.0002175995,0.0000911528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004919763,"about_ca_system_score_gemma":0.0002519359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002109516,"about_ca_topic_score_gemma":0.000009464876,"domain_scores_codex":[0.9970841,0.0005646748,0.0004757333,0.001024877,0.0002483418,0.0006022732],"domain_scores_gemma":[0.9986162,0.00007086966,0.0001786943,0.0005315988,0.0002110854,0.0003915917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003955642,0.00007069311,0.0004247283,0.00005997262,0.0002314629,0.0007023018,0.0003006744,0.0001449559,0.9942077,0.00004852811,0.0005744045,0.002839039],"study_design_scores_gemma":[0.00119471,0.001035551,0.0005594366,0.0000108614,0.0000958173,0.0000534329,0.00007982917,0.000527807,0.8604156,0.00005595949,0.1355256,0.0004454346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689178,0.01069565,0.01695463,0.002128491,0.0002243071,0.0004273811,0.00003188151,0.00008745158,0.0005323441],"genre_scores_gemma":[0.9936683,0.0002497256,0.001452131,0.003748835,0.0002541081,0.00006441132,0.0002176173,0.00009578263,0.0002490863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1349511,"threshold_uncertainty_score":0.9997853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518973886453803,"score_gpt":0.2447669607258422,"score_spread":0.2295772218613042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}