{"id":"W3084265147","doi":"10.1177/2398212820957847","title":"(2 <i>S</i> ,6 <i>S</i> )- and (2 <i>R</i> ,6 <i>R</i> )-hydroxynorketamine inhibit the induction of NMDA receptor-dependent LTP at hippocampal CA1 synapses in mice","year":2020,"lang":"en","type":"article","venue":"Brain and Neuroscience Advances","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Long-term potentiation; NMDA receptor; LTP induction; Hippocampal formation; Synaptic plasticity; Hippocampus; Mechanism of action; Ketamine; Chemistry; Pharmacology; AMPA receptor; Glutamate receptor; Receptor; Long-term depression; Neuroscience; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0005958293,0.0003265821,0.0003813775,0.0001570599,0.0006022073,0.0001080663,0.0007524319,0.00007610685,0.00001598983],"category_scores_gemma":[0.002013325,0.0002434466,0.00005617847,0.001564355,0.002757574,0.001034932,0.0007031549,0.0005534771,0.00001004248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002295364,"about_ca_system_score_gemma":0.00008060528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001418739,"about_ca_topic_score_gemma":0.00001994729,"domain_scores_codex":[0.9960605,0.0005902238,0.0005087039,0.001383088,0.0007510314,0.0007064486],"domain_scores_gemma":[0.9978948,0.001234353,0.0002486374,0.0002593011,0.00003596942,0.0003269668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001861884,0.00007358053,0.003055551,0.0000533756,5.068986e-7,0.00003661307,0.0003599661,0.00008547612,0.9932593,0.0001357937,0.0004399128,0.002313714],"study_design_scores_gemma":[0.0008275192,0.0005605496,0.0009840735,0.00002424808,0.000004890451,0.0001302863,0.0001233564,0.0003142788,0.9764725,0.0001028363,0.02021268,0.0002427676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827352,0.0006342416,0.00001293632,0.01514898,0.0004900177,0.000575117,0.00004084429,0.00006209652,0.000300588],"genre_scores_gemma":[0.9663824,0.006248237,0.00001139096,0.02696058,0.00007547392,0.00004089171,4.720158e-7,0.0000241191,0.0002564732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01977277,"threshold_uncertainty_score":0.9999564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03717382128531638,"score_gpt":0.2965970717909363,"score_spread":0.2594232505056199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}