{"id":"W3084306916","doi":"10.1074/jbc.ra120.014761","title":"Cholesterol sensing by CD81 is important for hepatitis C virus entry","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Deutsche Forschungsgemeinschaft; Wellcome Trust; Wellcome","keywords":"CD81; Allosteric regulation; Cholesterol; Mutant; Chemistry; Hepatitis C virus; Biochemistry; Receptor; Cell biology; Biology; Virus; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006005515,0.000198592,0.0002539328,0.0000783354,0.0005404411,0.000483131,0.0001659968,0.0003515348,0.002184219],"category_scores_gemma":[0.0002174924,0.0001249156,0.0002102939,0.0001041423,0.0002721406,0.0003961707,0.0002519829,0.0002620611,0.0002581541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004050788,"about_ca_system_score_gemma":0.0004880462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003183257,"about_ca_topic_score_gemma":0.002677939,"domain_scores_codex":[0.9999428,0.000008903496,0.000002964037,0.000009266138,0.00001681366,0.00001924647],"domain_scores_gemma":[0.9999605,0.00000899918,0.0000087977,0.000004258832,0.000007588801,0.00000970928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009198608,0.0002221793,0.01872196,0.0003471442,0.0001190111,0.0007725757,0.0003237533,0.1291584,0.8108978,0.01764763,0.001286429,0.01958326],"study_design_scores_gemma":[0.0003043465,0.0006959853,0.05050996,0.00007156093,0.0001935289,0.0006149024,0.0007496636,0.7077258,0.2105388,0.01454463,0.01390918,0.0001415992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923666,0.0004911106,0.002983458,0.0001806859,0.00002528904,0.00001258525,0.00006105076,0.00004853217,0.003830689],"genre_scores_gemma":[0.9983385,0.0002687728,0.000823388,0.00003467323,0.000003636478,0.000008606307,0.00006488447,0.000009813539,0.000447597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003183257,"threshold_uncertainty_score":0.007306933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04754600740671293,"score_gpt":0.3151855325036355,"score_spread":0.2676395250969225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}