{"id":"W3084362932","doi":"10.12688/f1000research.25637.2","title":"Inducible TDG knockout models to study epigenetic regulation","year":2020,"lang":"en","type":"preprint","venue":"F1000Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Universität Basel; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Epigenetics; DNA demethylation; DNA methylation; Embryonic stem cell; Cell biology; DNA repair; Reprogramming; Gene targeting; Epigenome; Genetics; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009226727,0.0003516027,0.0003453757,0.0002330585,0.0001582657,0.0001623575,0.000811688,0.0004789717,0.0001011171],"category_scores_gemma":[0.0002344786,0.0003773406,0.0001463733,0.0003129875,0.00004942227,0.000003864534,0.002687113,0.0005773572,0.0001334587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005852136,"about_ca_system_score_gemma":0.0003796809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002506885,"about_ca_topic_score_gemma":0.00008501309,"domain_scores_codex":[0.9964338,0.0004548508,0.0004845838,0.001310432,0.000814161,0.0005021638],"domain_scores_gemma":[0.9976658,0.00003082699,0.0001150544,0.00135968,0.0004295252,0.0003991399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003970187,0.0007038305,0.004776596,0.0001751305,0.0003693601,0.00002172966,0.001932714,0.1019528,0.8532978,0.0001932252,0.003915116,0.03226463],"study_design_scores_gemma":[0.00125271,0.002848176,0.0527762,0.00008396983,0.0001039177,0.000001395108,0.0004711495,0.01133818,0.8809195,0.03354521,0.01539877,0.001260863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954592,0.002030489,0.03600183,0.0009106003,0.0003283454,0.002674134,0.00007417271,0.00004716184,0.003341222],"genre_scores_gemma":[0.993489,0.0003454908,0.002752626,0.0001170387,0.0007665902,0.0003692592,0.0005558382,0.0001101626,0.001494018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09061465,"threshold_uncertainty_score":0.9998679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1502960327116382,"score_gpt":0.3833252217884402,"score_spread":0.233029189076802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}