{"id":"W3084362932","doi":"10.12688/f1000research.25637.2","title":"Inducible TDG knockout models to study epigenetic regulation","year":2020,"lang":"en","type":"preprint","venue":"F1000Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Universität Basel; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Epigenetics; DNA demethylation; DNA methylation; Embryonic stem cell; Cell biology; DNA repair; Reprogramming; Gene targeting; Epigenome; Genetics; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004429714,0.0009837699,0.0004496908,0.001180966,0.000347735,0.000555597,0.0008899443,0.001004936,0.006159156],"category_scores_gemma":[0.0002537163,0.0003651642,0.0006944981,0.000431843,0.0006485073,0.0004727647,0.0007120282,0.002057508,0.00198476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006604056,"about_ca_system_score_gemma":0.0004778083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006627673,"about_ca_topic_score_gemma":0.001281834,"domain_scores_codex":[0.9994637,0.00007586597,0.00007311701,0.0001584286,0.0001544966,0.0000742455],"domain_scores_gemma":[0.9995183,0.00006669118,0.0001729747,0.00009139559,0.0000505216,0.0001001108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009211773,0.00005288006,0.0001751024,0.00008516809,0.00001312256,0.0001279521,0.00002962308,0.0001460047,0.9954873,0.001091823,0.0002469497,0.002451933],"study_design_scores_gemma":[0.00005470416,0.0004562638,0.001627692,0.00004107947,0.00005595926,0.0009751705,0.00005240183,0.001149234,0.9721792,0.000460136,0.02293028,0.00001777265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7661277,0.005950702,0.1943544,0.0009785049,0.0007187863,0.001168243,0.01396988,0.003510144,0.01322156],"genre_scores_gemma":[0.8454172,0.005798833,0.08403738,0.0005625618,0.00008784208,0.002287677,0.01297275,0.001388733,0.04744697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006159156,"threshold_uncertainty_score":0.02060443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1502960327116382,"score_gpt":0.3833252217884402,"score_spread":0.233029189076802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}