{"id":"W3084377968","doi":"10.1016/s2213-2600(20)30389-1","title":"Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial","year":2020,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":258,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Sanofi Genzyme; University of Oxford; Sunovion; GlaxoSmithKline foundation; Boston Scientific Corporation; Sanofi; Mylan; GlaxoSmithKline; Regeneron Pharmaceuticals; Teva Pharmaceutical Industries; Genentech; AstraZeneca","keywords":"Medicine; Double blind; Asthma; Inhaler; Single blind; Physical therapy; Randomized controlled trial; Internal medicine; Alternative medicine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002131007,0.002030508,0.005324346,0.0005107367,0.0005662045,0.00145449,0.001432093,0.003348436,0.007659606],"category_scores_gemma":[0.002358249,0.0008979363,0.002901593,0.0004749711,0.001694715,0.001594377,0.0004821357,0.004248547,0.001249468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009020018,"about_ca_system_score_gemma":0.001043968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001406568,"about_ca_topic_score_gemma":0.001912225,"domain_scores_codex":[0.9991667,0.0004023114,0.00005284202,0.0001795843,0.00005667699,0.000141757],"domain_scores_gemma":[0.998353,0.0006288827,0.0003039725,0.0001291464,0.00008258106,0.0005023819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9905515,0.001612148,0.0001685253,0.0002768316,0.0003862603,0.00001055192,0.00002170388,0.00008126037,0.0009853237,0.00003390119,0.0002449415,0.005627217],"study_design_scores_gemma":[0.9593189,0.03905815,0.0007622796,0.00002123365,0.0002528833,0.00001280557,0.00001173768,0.0001994351,0.0001642403,0.00005648522,0.0001310617,0.00001086136],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865342,0.007170582,0.0005025001,0.0006949489,0.0007171595,0.001771757,0.0008517665,0.0001431027,0.001614017],"genre_scores_gemma":[0.9892578,0.002578466,0.001306426,0.001072347,0.0007567171,0.001741135,0.0008653217,0.0000363865,0.00238536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007659606,"threshold_uncertainty_score":0.02562398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09647644203234865,"score_gpt":0.3370647756047384,"score_spread":0.2405883335723897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}