{"id":"W3084377968","doi":"10.1016/s2213-2600(20)30389-1","title":"Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial","year":2020,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":258,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Sanofi Genzyme; University of Oxford; Sunovion; GlaxoSmithKline foundation; Boston Scientific Corporation; Sanofi; Mylan; GlaxoSmithKline; Regeneron Pharmaceuticals; Teva Pharmaceutical Industries; Genentech; AstraZeneca","keywords":"Medicine; Double blind; Asthma; Inhaler; Single blind; Physical therapy; Randomized controlled trial; Internal medicine; Alternative medicine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001384677,0.0005593091,0.00257334,0.000231662,0.000155918,0.00002234139,0.0003543565,0.000202554,0.0002642745],"category_scores_gemma":[0.001097387,0.0002950464,0.0001973999,0.0007181741,0.0007957557,0.0001406158,0.00006681826,0.0006220678,0.00001015594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000954681,"about_ca_system_score_gemma":0.0004186811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002971991,"about_ca_topic_score_gemma":0.00001815829,"domain_scores_codex":[0.9956834,0.000668741,0.001333814,0.000638044,0.001056794,0.000619163],"domain_scores_gemma":[0.9968699,0.0008996614,0.0006823699,0.0007047451,0.0002929363,0.0005504343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9663973,0.001434028,0.00144502,0.0001225251,0.0004033585,0.0001028262,0.001120405,0.00002227273,0.001316049,0.00005240598,0.00105245,0.02653131],"study_design_scores_gemma":[0.9349441,0.02939058,0.004818,0.0004158665,0.0003443156,0.000002445942,0.0003682582,0.00009082362,0.0004918229,0.000004181418,0.02883172,0.0002978602],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825937,0.004019147,0.0000442556,0.003616098,0.0003333923,0.007552473,0.00002991404,0.00009105056,0.00171998],"genre_scores_gemma":[0.9935284,0.0001867007,0.00002324357,0.003719309,0.002137064,0.0002342168,0.00004927318,0.00007134657,0.00005047625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03145323,"threshold_uncertainty_score":0.9999502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09647644203234865,"score_gpt":0.3370647756047384,"score_spread":0.2405883335723897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}